Anti-Kappa light chain抗体[A8B5] (ab79558)

概述

  • 产品名称Anti-Kappa light chain抗体[A8B5]
    参阅全部 Kappa light chain 一抗
  • 描述
    小鼠单克隆抗体[A8B5] to Kappa light chain
  • 经测试应用适用于: ELISA, IHC-P, IHC-Fr, Flow Cytmore details
  • 种属反应性
    与反应: Human
    不与反应: Sheep, Rabbit, Goat, Guinea pig, Hamster
  • 免疫原

    The details of the immunogen for this antibody are not available.

  • 阳性对照
    • Daudi human cell line.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: 15mM Sodium Azide
    Constituents: PBS, pH 7.4
  • Concentration information loading...
  • 纯度Protein A purified
  • 纯化说明ab79558 is purified from hybridoma culture supernatant by protein A affinity chromatography. Purity is > 95% (by SDS-PAGE).
  • 克隆单克隆
  • 克隆编号A8B5
  • 同种型IgG1
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab79558 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA Use at an assay dependent concentration.
IHC-P Use at an assay dependent concentration.
IHC-Fr Use at an assay dependent concentration.
Flow Cyt Use at an assay dependent concentration. ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

靶标

  • 相关性Immunoglobulins belong to a group of related glyco proteins which make up 20% of serum proteins. Antigens and immunoglobulins react to confer immunity to individuals. Immunoglobulins have similar structures of two identical heavy chains and two identical light chains. Both the heavy chains and the light chains are divided into constant and variable regions. The constant regions have the same amino acid sequences between all the immunoglobulin classes. The variable regions have approximately 110 amino acids with high sequence variability. The amino acid sequence of the heavy chain determines the class of an immunoglobulin. The five types of immunoglobulin heavy chains are known as: IgG, IgA, IgM, IgD, and IgE. IgG is divided into four subclasses, and IgA is divided into two subclasses. In serum IgA and IgG are monomers with a single 4 polypeptide unit; while, IgM is a pen tamer. IgA may also form polymers. Kappa light chain antibody can be used for the identification of leukemias, plasmacytomas and certain non Hodgkin's lymphomas. Kappa light chain contains one immunoglobulin like domain. The EU sequence has the INV allotypic marker, Ala 45 and Val 83. The ROY sequence has the INV allotypic marker, Ala 45 and Leu 83.
  • 细胞定位Cytoplasmic and Secreted
  • 数据库链接
  • 别名
    • HCAK 1 antibody
    • HCAK1 antibody
    • Ig kappa chain C region antibody
    • IGKC antibody
    • IGKCD antibody
    • Immunoglobulin InV antibody
    • Immunoglobulin kappa constant antibody
    • Immunoglobulin kappa constant region antibody
    • Immunoglobulin kappa light chain antibody
    • Immunoglobulin kappa light chain constant region antibody
    • Immunoglobulin KM antibody
    • Kappa 1 immunoglobulin light chain antibody
    • kappa light chain antibody
    • Km antibody
    • MGC111575 antibody
    • MGC62011 antibody
    • MGC72072 antibody
    • MGC88770 antibody
    • MGC88771 antibody
    • MGC88809 antibody
    see all

Anti-Kappa light chain antibody [A8B5] 图像

  • ab79558 detecting Kappa light chain in B lymphocytes by Flow cytometry. B lymphocytes (CD19+) in a dot-plot Lambda PE vs. Kappa FITC. Kappa light chain detected by A8B5 antibody and lambda light chain by 4C2, CD19 by LT19 antibody (ab8331).

Anti-Kappa light chain antibody [A8B5] (ab79558)参考文献

This product has been referenced in:
  • Di Bartolo DL  et al. Role of defective Oct-2 and OCA-B expression in immunoglobulin production and Kaposi's sarcoma-associated herpesvirus lytic reactivation in primary effusion lymphoma. J Virol 83:4308-15 (2009). Read more (PubMed: 19224997) »
  • Scheeren FA  et al. IL-21 is expressed in Hodgkin lymphoma and activates STAT5: evidence that activated STAT5 is required for Hodgkin lymphomagenesis. Blood 111:4706-15 (2008). Read more (PubMed: 18296629) »

See all 3 Publications for this product

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