概述

  • 产品名称Anti-KALRN抗体
    参阅全部 KALRN 一抗
  • 描述
    兔多克隆抗体to KALRN
  • 经测试应用适用于: Functional Studies, ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Horse, Chicken, Cow, Dog
  • 免疫原

    Synthetic peptide:

    KEPLQLPKTPAKQRN

    conjugated to KLH, corresponding to amino acids 1591-1605 of Human KALRN (NP_001019831.2).

  • 阳性对照
    • Human skeletal muscle tissue.

性能

应用

Our Abpromise guarantee covers the use of ab115235 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Functional Studies Use a concentration of 10 µg/ml. (agonist)
ELISA 1/1 - 1/1000.
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity.
  • 组织特异性Isoform 2 is brain specific. Highly expressed in cerebral cortex, putamen, amygdala, hippocampus and caudate nucleus. Weakly expressed in brain stem and cerebellum. Isoform 4 is expressed in skeletal muscle.
  • 疾病相关Genetic variation in KALRN is associated with susceptibility to coronary heart disease type 5 (CHDS5) [MIM:608901]. CHD is the leading cause of death and disability worldwide. CHD is multifactorial disease with a strong genetic component. Classic epidemiologic studies have revealed many risk factors for CHD, including age, sex, hypertension, dyslipidemia, diabetes mellitus, smoking, and physical inactivity.
  • 序列相似性Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
    Contains 1 CRAL-TRIO domain.
    Contains 2 DH (DBL-homology) domains.
    Contains 1 fibronectin type-III domain.
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    Contains 2 PH domains.
    Contains 1 protein kinase domain.
    Contains 2 SH3 domains.
    Contains 5 spectrin repeats.
  • 结构域The two GEF domains catalyze nucleotide exchange for RAC1 and RhoA which are bound by DH1 and DH2 respectively. The two GEF domains appear to play differing roles in neuronal development and axonal outgrowth. SH3 1 binds to the first GEF domain inhibiting GEF activity only when in the presence of a PXXP peptide, suggesting that the SH3 domain/peptide interaction mediates binding to GEF1. CRK1 SH3 domain binds to and inhibits GEF1 activity.
  • 翻译后修饰Autophosphorylated.
  • 细胞定位Cytoplasm. Cytoplasm > cytoskeleton. Associated with the cytoskeleton.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Duo antibody
    • FLJ16443 antibody
    • HAPIP antibody
    • Huntingtin associated protein interacting protein (duo) antibody
    • Huntingtin-associated protein-interacting protein antibody
    • Kalirin (isoform 2) antibody
    • Kalirin antibody
    • KALRN antibody
    • KALRN_HUMAN antibody
    • Protein Duo antibody
    • RhoGEF kinase antibody
    • Serine/threonine kinase with Dbl and pleckstrin homology domains antibody
    • Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain antibody
    • TRAD antibody
    see all

Anti-KALRN antibody 图像

  • Human skeletal muscle tissue (formalin-fixed, paraffin-embedded) stained with ab115235 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-KALRN antibody (ab115235)参考文献

ab115235 has not yet been referenced specifically in any publications.

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