概述

  • 产品名称Anti-Kallikrein 6抗体[9A7]
    参阅全部 Kallikrein 6 一抗
  • 描述
    小鼠单克隆抗体[9A7] to Kallikrein 6
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant human protein purified from E.coli

  • 阳性对照
    • Bosc23 cell lysate transfectedwith neurosin

性能

应用

Our Abpromise guarantee covers the use of ab51057 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000. Detects a band of approximately 32 kDa (predicted molecular weight: 27 kDa).

靶标

  • 功能Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.
  • 组织特异性In fluids, highest levels found in milk of lactating women followed by cerebrospinal fluid, nipple aspirate fluid and breast cyst fluid. Also found in serum, seminal plasma and some amniotic fluids and breast tumor cytosolic extracts. Not detected in urine. At the tissue level, highest concentrations found in glandular tissues such as salivary glands followed by lung, colon, fallopian tube, placenta, breast, pituitary and kidney. Not detected in skin, spleen, bone, thyroid, heart, ureter, liver, muscle, endometrium, testis, pancreas, seminal vesicle, ovary, adrenals and prostate. In brain, detected in gray matter neurons (at protein level). Colocalizes with pathological inclusions such as Lewy bodies and glial cytoplasmic inclusions. Overexpressed in primary breast tumors but not expressed in metastatic tumors.
  • 序列相似性Belongs to the peptidase S1 family. Kallikrein subfamily.
    Contains 1 peptidase S1 domain.
  • 翻译后修饰Inactivated by autolytic cleavage after Arg-80.
  • 细胞定位Secreted. Nucleus > nucleolus. Cytoplasm. Mitochondrion. Microsome. In brain, detected in the nucleus of glial cells and in the nucleus and cytoplasm of neurons. Detected in the mitochondrial and microsomal fractions of HEK-293 cells and released into the cytoplasm following cell stress.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Bssp antibody
    • hK 6 antibody
    • hK6 antibody
    • Kallikrein 6 precursor antibody
    • Kallikrein related peptidase 6 antibody
    • Kallikrein-6 antibody
    • Kallikrein6 antibody
    • KLK 6 antibody
    • Klk 7 antibody
    • KLK 9 antibody
    • Klk29 antibody
    • Klk6 antibody
    • KLK6_HUMAN antibody
    • Klk7 antibody
    • KLK9 antibody
    • MGC9355 antibody
    • mGK 1 antibody
    • mGK1 antibody
    • MSP antibody
    • Neurosin antibody
    • Protease M antibody
    • Protease serine 18 antibody
    • Protease serine 9 antibody
    • PRSS 18 antibody
    • PRSS 9 antibody
    • PRSS18 antibody
    • PRSS9 antibody
    • Serine protease 18 antibody
    • Serine protease 9 antibody
    • SP 59 antibody
    • SP59 antibody
    • Tissue kallikrein antibody
    • TK antibody
    • Zyme antibody
    see all

Anti-Kallikrein 6 antibody [9A7] 图像

  • All lanes : Anti-Kallikrein 6 antibody [9A7] (ab51057) at 1/1000 dilution

    Lane 1 : Bosc23 cell lysate transfected with GFP
    Lane 2 : Bosc23 cell lysate transfected with myc/His-neurosin
    Lane 3 : Bosc23 cell lysate transfected with myc/His-Gpx3


    Predicted band size : 27 kDa
    Observed band size : 30 kDa (why is the actual band size different from the predicted?)

Anti-Kallikrein 6 antibody [9A7] (ab51057)参考文献

This product has been referenced in:
  • Park JE  et al. Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes. Mol Cell Proteomics 9:1085-99 (2010). WB ; Human . Read more (PubMed: 20124223) »

See 1 Publication for this product

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