概述

  • 产品名称Anti-K0776抗体
    参阅全部 K0776 一抗
  • 描述
    兔多克隆抗体to K0776
  • 经测试应用适用于: IPmore details
    不适用于: WB
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Horse, Guinea pig, Dog, Pig, Chimpanzee, Rhesus monkey, Gorilla, Orangutan
  • 免疫原

    Synthetic peptide, corresponding to a region within amino acids 175-225 of Human K0776 using the numbering given in entry NP_056138.1.

  • 阳性对照
    • HeLa whole cell lysate

性能

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应用

Our Abpromise guarantee covers the use of ab123500 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IP Use at 2-10 µg/mg of lysate.
  • 应用说明Is unsuitable for WB.
  • 靶标

    • 功能E3 UFM1-protein ligase that mediates ufmylation of target proteins such as DDRGK1/C20orf116. The function of ufmylation is unknown. May act as a tumor suppressor by inhibiting cell invasion, blocking NF-kappa-B signaling and increasing stability of CDK5RAP3.
    • 组织特异性Ubiquitously expressed, with a high expression in liver (at protein level). Low expression in several invasive hepatocellular carcinomas, such HepG2, Hep3B, HLE and PLC.
    • 序列相似性Belongs to the UFL1 family.
    • 翻译后修饰Ubiquitinated, leading to its degradation by the proteasome. Interaction with CDK5RAP3 protects each other against ubiquitination and degradation via the proteasome.
    • 细胞定位Endoplasmic reticulum. Cytoplasm. In cytoplasm colocalizes with CDK5RAP3.
    • Information by UniProt
    • 数据库链接
    • 别名
      • E3 UFM1-protein ligase 1 antibody
      • KIAA0776 antibody
      • LZAP-binding protein antibody
      • Maxer antibody
      • NLBP antibody
      • RCAD antibody
      • UFL1 antibody
      • UFL1_HUMAN antibody
      see all

    Anti-K0776 antibody 图像

    • Immunoprecipitation from HeLa whole cell lysate (1 mg for IP, 20% of IP loaded), using ab123500 for IP at 6 µg/mg lysate.
      Subsequent Western blot detection used an antibody which recognized a downstream epitope of K0776 at 0.4 µg/ml.
      Detection: Chemiluminescence with an exposure time of 10 seconds.

    Anti-K0776 antibody (ab123500)参考文献

    ab123500 has not yet been referenced specifically in any publications.

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