Anti-UFL1抗体(ab123500)
Key features and details
- Rabbit polyclonal to UFL1
- Suitable for: IP
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-UFL1抗体
参阅全部 UFL1 一抗 -
描述
兔多克隆抗体to UFL1 -
宿主
Rabbit -
经测试应用
适用于: IPmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat, Horse, Guinea pig, Dog, Pig, Chimpanzee, Rhesus monkey, Gorilla, Orangutan -
免疫原
Synthetic peptide corresponding to Human UFL1 aa 175-225.
Database link: NP_056138.1 -
阳性对照
- HeLa whole cell lysate
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7.00
Preservative: 0.09% Sodium azide
Constituent: 99% Tris citrate/phosphate
pH 7 to 8 -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab123500于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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IP |
Use at 2-10 µg/mg of lysate.
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说明 |
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IP
Use at 2-10 µg/mg of lysate. |
靶标
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功能
E3 UFM1-protein ligase that mediates ufmylation of target proteins such as DDRGK1/C20orf116. The function of ufmylation is unknown. May act as a tumor suppressor by inhibiting cell invasion, blocking NF-kappa-B signaling and increasing stability of CDK5RAP3. -
组织特异性
Ubiquitously expressed, with a high expression in liver (at protein level). Low expression in several invasive hepatocellular carcinomas, such HepG2, Hep3B, HLE and PLC. -
序列相似性
Belongs to the UFL1 family. -
翻译后修饰
Ubiquitinated, leading to its degradation by the proteasome. Interaction with CDK5RAP3 protects each other against ubiquitination and degradation via the proteasome. -
细胞定位
Endoplasmic reticulum. Cytoplasm. In cytoplasm colocalizes with CDK5RAP3. - Information by UniProt
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数据库链接
- Entrez Gene: 462889 Chimpanzee
- Entrez Gene: 101150106 Gorilla
- Entrez Gene: 100065945 Horse
- Entrez Gene: 23376 Human
- Entrez Gene: 67490 Mouse
- Entrez Gene: 313115 Rat
- Entrez Gene: 704454 Rhesus monkey
- Omim: 613372 Human
see all -
别名
- E3 UFM1-protein ligase 1 antibody
- KIAA0776 antibody
- LZAP-binding protein antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab123500 尚未被引用在任何文献中。