• 产品名称Anti-Junctophilin-2抗体
    参阅全部 Junctophilin-2 一抗
  • 描述
    兔多克隆抗体to Junctophilin-2
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    A synthetic 17 amino acid peptide near the carboxy terminus of human Junctophilin-2 (NP_065166)

  • 阳性对照
    • Mouse brain tissue lysate


  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C.
  • 存储溶液Preservative: 0.02% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明Affinity chromatography purified via peptide column
  • 克隆多克隆
  • 同种型IgG
  • 研究领域



Our Abpromise guarantee covers the use of ab79071 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 74 kDa.Can be blocked with Junctophilin-2 peptide (ab110064).
ELISA Use at an assay dependent dilution.


  • 功能Contributes to the stabilization of the junctional membrane complexes, which are common to excitable cells and mediate cross-talk between cell surface and intracellular ion channels. Probably acts by anchoring the plasma membrane and endoplasmic/sarcoplasmic reticulum. Contributes to the construction of skeletal muscle triad junctions, and plays an essential role in heart development.
  • 组织特异性Specifically expressed in skeletal muscle and heart.
  • 疾病相关Defects in JPH2 are the cause of cardiomyopathy familial hypertrophic type 17 (CMH17) [MIM:613873]. CMH17 is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
  • 序列相似性Belongs to the junctophilin family.
    Contains 8 MORN repeats.
  • 结构域The MORN (membrane occupation and recognition nexus) repeats contribute to the plasma membrane binding, possibly by interacting with phospholipids.
  • 细胞定位Cell membrane. Endoplasmic reticulum membrane. Sarcoplasmic reticulum membrane. Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic/sarcoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane. In heart cells, it predominantly associates along Z lines within myocytes. In skeletal muscle, it is specifically localized at the junction of A and I bands.
  • Information by UniProt
  • 数据库链接
  • 别名
    • FLJ40969 antibody
    • JP-2 antibody
    • JP2 antibody
    • Jph2 antibody
    • JPH2_HUMAN antibody
    • Junctophilin 2 antibody
    • Junctophilin type 2 antibody
    • Junctophilin-2 antibody
    • OTTHUMP00000031651 antibody
    • OTTHUMP00000031652 antibody
    see all

Anti-Junctophilin-2 antibody 图像

  • Lane 1 : Anti-Junctophilin-2 antibody (ab79071) at 1 µg/ml
    Lane 2 : Anti-Junctophilin-2 antibody (ab79071) at 2 µg/ml

    Lane 1 : mouse brain tissue lysate
    Lane 2 : mouse brain tissue lysate

    Lysates/proteins at 15 µg per lane.

    Predicted band size : 74 kDa
    Observed band size : 74 kDa
    Additional bands at : 64 kDa (possible isoform).

Anti-Junctophilin-2 antibody (ab79071)参考文献

ab79071 has not yet been referenced specifically in any publications.

Product Wall

Application Western blot
Loading amount 10 µg
Gel Running Conditions Reduced Denaturing (8%)
Sample Sheep Tissue lysate - whole (Cardiac)
Specification Cardiac
Blocking step Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 22°C

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提交于 Nov 15 2013