Anti-JP-2抗体(ab110056)
Key features and details
- Rabbit polyclonal to JP-2
- Suitable for: WB, IHC-P
- Reacts with: Mouse, Human
- Isotype: IgG
概述
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产品名称
Anti-JP-2抗体
参阅全部 JP-2 一抗 -
描述
兔多克隆抗体to JP-2 -
宿主
Rabbit -
特异性
Multiple isoforms of JPH2 are known to exist. -
经测试应用
适用于: WB, IHC-Pmore details -
种属反应性
与反应: Mouse, Human
预测可用于: Rat -
免疫原
Synthetic peptide corresponding to Human JP-2 (C terminal).
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阳性对照
- Human Heart and Skeletal Muscle. Mouse brain tissue lysate.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
存储溶液
pH: 7.4
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab110056于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 75 kDa.
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IHC-P |
Use a concentration of 5 µg/ml.
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说明 |
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WB
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 75 kDa. |
IHC-P
Use a concentration of 5 µg/ml. |
靶标
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功能
Contributes to the stabilization of the junctional membrane complexes, which are common to excitable cells and mediate cross-talk between cell surface and intracellular ion channels. Probably acts by anchoring the plasma membrane and endoplasmic/sarcoplasmic reticulum. Contributes to the construction of skeletal muscle triad junctions, and plays an essential role in heart development. -
组织特异性
Specifically expressed in skeletal muscle and heart. -
疾病相关
Defects in JPH2 are the cause of cardiomyopathy familial hypertrophic type 17 (CMH17) [MIM:613873]. CMH17 is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. -
序列相似性
Belongs to the junctophilin family.
Contains 8 MORN repeats. -
结构域
The MORN (membrane occupation and recognition nexus) repeats contribute to the plasma membrane binding, possibly by interacting with phospholipids. -
细胞定位
Cell membrane. Endoplasmic reticulum membrane. Sarcoplasmic reticulum membrane. Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic/sarcoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane. In heart cells, it predominantly associates along Z lines within myocytes. In skeletal muscle, it is specifically localized at the junction of A and I bands. - Information by UniProt
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数据库链接
- Entrez Gene: 57158 Human
- Entrez Gene: 59091 Mouse
- Entrez Gene: 296345 Rat
- Omim: 605267 Human
- SwissProt: Q9BR39 Human
- SwissProt: Q9ET78 Mouse
- SwissProt: Q2PS20 Rat
- Unigene: 441737 Human
see all -
别名
- FLJ40969 antibody
- JP-2 antibody
- JP2 antibody
see all
图片
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Lane 1 : Anti-JP-2 antibody (ab110056) at 1 µg/ml
Lane 2 : Anti-JP-2 antibody (ab110056) at 2 µg/ml
All lanes : Mouse brain tissue lysate
Predicted band size: 75 kDa -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-JP-2 antibody (ab110056)
ab110056 at 5 µg/ml staining JP-2 in Formalin-Fixed, Paraffin-Embedded Human Heart by Immunohistochemistry.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-JP-2 antibody (ab110056)
ab110056 at 5 µg/ml staining JP-2 in Formalin-Fixed, Paraffin-Embedded Human Skeletal Muscle by Immunohistochemistry.
数据表及文件
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SDS download
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Datasheet download
文献 (1)
ab110056 被引用在 1 文献中.
- Huang X et al. Identification of Crucial Genes and Key Functions in Type 2 Diabetic Hearts by Bioinformatic Analysis. Front Endocrinol (Lausanne) 13:801260 (2022). PubMed: 35242109