Anti-Junctional Adhesion Molecule C抗体[MM0426-4M35] (ab89665)
概述
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产品名称Anti-Junctional Adhesion Molecule C抗体[MM0426-4M35]
参阅全部 Junctional Adhesion Molecule C 一抗 -
描述小鼠单克隆抗体[MM0426-4M35] to Junctional Adhesion Molecule C
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经测试应用适用于: WB, Neutralisingmore details
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种属反应性与反应: Human
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免疫原
Recombinant full length Human Junctional Adhesion Molecule C protein.
性能
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形式Liquid
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存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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存储溶液Preservative: None
Constituents: PBS -
Concentration information loading... -
纯度Protein G purified
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纯化说明The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and 0.2 µm filtered.
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克隆单克隆
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克隆编号MM0426-4M35
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同种型IgG1
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研究领域
相关产品
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Compatible Secondaries
应用
Our Abpromise guarantee covers the use of ab89665 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB | 1/500 - 1/1000. Predicted molecular weight: 35 kDa. | |
| Neutralising | Use at an assay dependent dilution. |
靶标
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功能Participates in cell-cell adhesion. It is a counterreceptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN). The soluble form is a mediator of angiogenesis.
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组织特异性Highest expression in placenta, brain and kidney. Significant expression is detected on platelets. Expressed in intestinal mucosa cells. Expressed in the vascular endothelium. Found in serum (at protein level). Also detected in the synovial fluid of patients with rheumatoid arthritis, psoriatic arthritis or ostearthritis (at protein level).
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疾病相关Defects in JAM3 are the cause of hemorrhagic destruction of the brain with subependymal calcification and cataracts (HDBSCC) [MIM:613730]. A syndrome characterized by congenital cataracts and severe brain abnormalities apparently resulting from hemorrhagic destruction of the brain tissue, including the cerebral white matter and basal ganglia. Patients manifest profound developmental delay, and other neurologic features included seizures, spasticity, and hyperreflexia. Brain imaging shows multifocal intraparenchymal hemorrhage with associated liquefaction and massive cystic degeneration, and calcification in the subependymal region and in brain tissue.
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序列相似性Belongs to the immunoglobulin superfamily.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 Ig-like V-type (immunoglobulin-like) domain. -
翻译后修饰Proteolytically cleaved from endothelial cells surface into a soluble form by ADAM10 and ADAM17; the release of soluble JAM3 is increased by proinflammatory factors.
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细胞定位Cell membrane. Cell junction > desmosome. Secreted > extracellular space. In epithelial cells, it is expressed at desmosomes but not at tight junctions. Localizes at the cell surface of endothelial cells; treatment of endothelial cells with vascular endothelial growth factor stimulates recruitement of JAM3 to cell-cell contacts.
- Information by UniProt
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数据库链接
- Entrez Gene: 83700 Human
- Omim: 606871 Human
- SwissProt: Q9BX67 Human
- Unigene: 150718 Human
- Unigene: 728339 Human
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别名
- FLJ14529 antibody
- JAM 2 antibody
- JAM 3 antibody
see all
Anti-Junctional Adhesion Molecule C antibody [MM0426-4M35] (ab89665)参考文献
ab89665 has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"