Anti-Junctional Adhesion Molecule C抗体[19 H36] (ab16889)

概述

  • 产品名称
    Anti-Junctional Adhesion Molecule C抗体[19 H36]
    参阅全部 Junctional Adhesion Molecule C 一抗
  • 描述
    大鼠单克隆抗体[19 H36] to Junctional Adhesion Molecule C
  • 经测试应用
    适用于: IP, Flow Cyt, IHC-Frmore details
    不适用于: IHC-P or WB
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    This information is considered to be commercially sensitive.

  • 阳性对照
    • High endothelial venules of lymphoid organs, lymphoendothelial cells and endothelial cells of the kidney

性能

应用

Our Abpromise guarantee covers the use of ab16889 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IP Use at an assay dependent concentration.
Flow Cyt Use at an assay dependent concentration. ab18450-Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody.
IHC-Fr Use at an assay dependent concentration.
  • 应用说明
    Is unsuitable for IHC-P or WB.
  • 靶标

    • 功能
      Participates in cell-cell adhesion. It is a counterreceptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN). The soluble form is a mediator of angiogenesis.
    • 组织特异性
      Highest expression in placenta, brain and kidney. Significant expression is detected on platelets. Expressed in intestinal mucosa cells. Expressed in the vascular endothelium. Found in serum (at protein level). Also detected in the synovial fluid of patients with rheumatoid arthritis, psoriatic arthritis or ostearthritis (at protein level).
    • 疾病相关
      Defects in JAM3 are the cause of hemorrhagic destruction of the brain with subependymal calcification and cataracts (HDBSCC) [MIM:613730]. A syndrome characterized by congenital cataracts and severe brain abnormalities apparently resulting from hemorrhagic destruction of the brain tissue, including the cerebral white matter and basal ganglia. Patients manifest profound developmental delay, and other neurologic features included seizures, spasticity, and hyperreflexia. Brain imaging shows multifocal intraparenchymal hemorrhage with associated liquefaction and massive cystic degeneration, and calcification in the subependymal region and in brain tissue.
    • 序列相似性
      Belongs to the immunoglobulin superfamily.
      Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
      Contains 1 Ig-like V-type (immunoglobulin-like) domain.
    • 翻译后修饰
      Proteolytically cleaved from endothelial cells surface into a soluble form by ADAM10 and ADAM17; the release of soluble JAM3 is increased by proinflammatory factors.
    • 细胞定位
      Cell membrane. Cell junction > desmosome. Secreted > extracellular space. In epithelial cells, it is expressed at desmosomes but not at tight junctions. Localizes at the cell surface of endothelial cells; treatment of endothelial cells with vascular endothelial growth factor stimulates recruitement of JAM3 to cell-cell contacts.
    • Information by UniProt
    • 数据库链接
    • 别名
      • FLJ14529 antibody
      • JAM 2 antibody
      • JAM 3 antibody
      • JAM C antibody
      • JAM-2 antibody
      • JAM-3 antibody
      • JAM-C antibody
      • JAM2 antibody
      • Jam3 antibody
      • JAM3_HUMAN antibody
      • JAMC antibody
      • Junctional adhesion molecule 3 antibody
      • Junctional adhesion molecule 3 precursor antibody
      • Junctional adhesion molecule C antibody
      see all

    文献

    ab16889 has not yet been referenced specifically in any publications.

    客户评价及客户问答

    Thank you once again for your recent enquiries. I have investigated this case and have obtained the following information for you regarding out JAMC and JAM 2 antibodies. I can understand the confusion, and hope this will help. The SwissProt/Unipro...

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    I'm sorry you have been experiencing a problem with ab16889. As positive control for staining JAM-2 on frozen sections murine tissue of high endothelial venules of lymphoid organs can be used. Or lymphoendothelial cells and the endothelial cells of ...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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