功能May play a role in the processes of lymphocyte homing to secondary lymphoid organs.
组织特异性Highest expression in the heart, placenta, lung, foreskin and lymph node. Prominently expressed on high endothelial venules, also present on the endothelia of other vessels. Localized to the intercellular boundaries of high endothelial cells.
序列相似性Belongs to the immunoglobulin superfamily. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 Ig-like V-type (immunoglobulin-like) domain.
细胞定位Cell junction > tight junction. Cell membrane. Localized at tight junctions of both epithelial and endothelial cells.