The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
应用说明WB: Use at a concentration of 0.3 - 2 µg/ml. Predicted molecular weight: 33 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
功能Seems to plays a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus.
序列相似性Belongs to the immunoglobulin superfamily. Contains 2 Ig-like V-type (immunoglobulin-like) domains.
细胞定位Cell junction > tight junction. Cell membrane. Localized at tight junctions of both epithelial and endothelial cells.