概述

  • 产品名称Anti-JPH1抗体
    参阅全部 JPH1 一抗
  • 描述
    小鼠单克隆抗体to JPH1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment: VADEQVTAIV NKPLMSKAPT KEAGAVVPQS KYSGRHHIPN PSNGELHSQY HGYYVKLNAP QHPPVDVEDG DGSSQSSSA, corresponding to amino acids 501-580 of Human JPH1

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: None
    PBS, pH 7.2
  • Concentration information loading...
  • 纯度Protein G purified
  • 克隆单克隆
  • 同种型IgG2a
  • 轻链类型kappa
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab57425 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes.
    • 组织特异性Abundantly expressed in skeletal muscle. Very low levels in heart.
    • 序列相似性Belongs to the junctophilin family.
      Contains 7 MORN repeats.
    • 结构域The MORN (membrane occupation and recognition nexus) repeats contribute to the plasma membrane binding, possibly by interacting with phospholipids.
    • 细胞定位Cell membrane. Endoplasmic reticulum membrane. Sarcoplasmic reticulum membrane. Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic/sarcoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane. In skeletal muscle cells, it is predominantly localized at the junction of the A and I bands.
    • Information by UniProt
    • 数据库链接
    • 别名
      • DKFZp762L0313 antibody
      • JP 1 antibody
      • JP-1 antibody
      • JP1 antibody
      • JPH 1 antibody
      • JPH1 antibody
      • JPH1_HUMAN antibody
      • Junctophilin 1 antibody
      • Junctophilin type 1 antibody
      • Junctophilin type1 antibody
      • Junctophilin-1 antibody
      • Junctophilin1 antibody
      • Mitsugumin 72 antibody
      • Mitsugumin72 antibody
      see all

    Anti-JPH1 antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab57425 JPH1 antibody at 1ug/ml. Predicted band size of immunogen is 35 kDa

    Anti-JPH1 antibody (ab57425)参考文献

    ab57425 has not yet been referenced specifically in any publications.

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