Anti-JNK1+JNK2抗体[279Q38] (ab37228)


  • 产品名称Anti-JNK1+JNK2抗体[279Q38]
    参阅全部 JNK1+JNK2 一抗
  • 描述
    小鼠单克隆抗体[279Q38] to JNK1+JNK2
  • 特异性ab37228 binds to both JNK1 and JNK2 proteins of molecular weight 46 and 54 kDa.
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Recombinant fragment (Human) from JNKalpha1 expressed in E.coli.

  • 阳性对照
    • Human Jurkat cells, mouse L929 cells and rat L6 cells.



Our Abpromise guarantee covers the use of ab37228 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
  • 应用说明WB: Use at a concentration of 1 µg/ml. Predicted molecular weight:- JNK1: 45 Kda; JNK2: 54 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells (By similarity). Phosphorylates heat shock factor protein 4 (HSF4).
      JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms.
    • 序列相似性Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
      Contains 1 protein kinase domain.
    • 结构域The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
    • 翻译后修饰Dually phosphorylated on Thr-183 and Tyr-185, which activates the enzyme.
    • Information by UniProt
    • 数据库链接
    • 别名
      • c jun N terminal kinase 2 antibody
      • c-Jun N-terminal kinase 1 antibody
      • cJun N terminal kinase 1 antibody
      • JNK 1 antibody
      • JNK 2 antibody
      • JNK-46 antibody
      • JNK2ALPHA antibody
      • JNK2BETA antibody
      • MAP kinase 8 antibody
      • MAP kinase 9 antibody
      • MAPK 8 antibody
      • mapk8 antibody
      • MAPK9 antibody
      • Mitogen activated protein kinase 8 antibody
      • Mitogen activated protein kinase 9 antibody
      • Mitogen-activated protein kinase 8 antibody
      • MK08_HUMAN antibody
      • PRKM 8 antibody
      • PRKM 9 antibody
      • Stress-activated protein kinase 1 antibody
      • Stress-activated protein kinase JNK1 antibody
      see all

    Anti-JNK1+JNK2 antibody [279Q38] 图像

    • Anti-JNK1+JNK2 antibody [279Q38] (ab37228) at 1 µg/ml + Cell extract of human Jurkat cells (10-30µg/lane total protein)

      Goat F(ab’)2 antimouse IgG, alkaline phosphatase conjugated antibody, at 1/2000 dilution

      Predicted band size : JNK1: 45 ; JNK2: 54 kDa
      Observed band size : 46,54 kDa (why is the actual band size different from the predicted?)

    Anti-JNK1+JNK2 antibody [279Q38] (ab37228)参考文献

    ab37228 has not yet been referenced specifically in any publications.

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