概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 序列VVWHKTVRGRPKLSRKWYRILKQEHPELAVLADSVDLQESTGIASDSSSD

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技术指标

Our Abpromise guarantee covers the use of ab110802 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-JMJD6 antibody (ab50720)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

    Constituent: 100% dH2O

常规信息

  • 别名
    • Apoptotic cell clearance receptor
    • Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
    • Histone arginine demethylase JMJD6
    • JmjC domain-containing protein 6
    • JMJD 6
    • JMJD6
    • JMJD6_HUMAN
    • Jumonji domain containing 6
    • Jumonji domain-containing protein 6
    • KIAA0585
    • Lysyl-hydroxylase JMJD6
    • Peptide-lysine 5-dioxygenase JMJD6
    • Phosphatidylserine receptor
    • Protein PTDSR
    • PSR
    • PTDSR
    • PTDSR 1
    • PTDSR1
    see all
  • 功能Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as a RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. Has no histone lysine demethylase activity. Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65. Seems to be necessary for the regulation of macrophage cytokine responses.
  • 组织特异性Highly expressed in the heart, skeletal muscle and kidney. Expressed at moderate or low level in brain, placenta, lung, liver, pancreas, spleen, thymus, prostate, testis and ovary. Up-regulated in many patients with chronic pancreatitis. Expressed in nursing thymic epithelial cells.
  • 序列相似性Belongs to the JMJD6 family.
    Contains 1 JmjC domain.
  • 结构域The nuclear localization signal motifs are necessary and sufficient to target it into the nucleus.
  • 细胞定位Nucleus > nucleoplasm. Nucleus > nucleolus. Mainly found throughout the nucleoplasm outside of regions containing heterochromatic DNA, with some localization in nucleolus. During mitosis, excluded from the nucleus and reappears in the telophase of the cell cycle.
  • Information by UniProt

JMJD6 peptide (ab110802)参考文献

ab110802 has not yet been referenced specifically in any publications.

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