Anti-JMJD1C抗体(ab106457)

概述

  • 产品名称Anti-JMJD1C抗体
    参阅全部 JMJD1C 一抗
  • 描述
    兔多克隆抗体to JMJD1C
  • 特异性ab106457 does not cross-react with JMJD1A or JMJD1B.
  • 经测试应用适用于: ICC/IF, IHC-P, WBmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    A 20 amino acid synthetic peptide from near the amino terminus of Human JMJD1C (NP_116165).

  • 阳性对照
    • WB: Human liver tissue lysate IHC-P: Rat liver tissue

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab106457 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF Use a concentration of 20 µg/ml.
IHC-P Use a concentration of 2.5 µg/ml. Perform heat mediated antigen retrieval via the microwave method before commencing with IHC staining protocol.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 285 kDa.

靶标

  • 功能Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes.
  • 序列相似性Belongs to the JHDM2 histone demethylase family.
    Contains 1 JmjC domain.
  • 结构域Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.
  • 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • JHD2C_HUMAN antibody
    • Jmjd1c antibody
    • Jumonji domain containing 1C antibody
    • Jumonji domain-containing protein 1C antibody
    • Probable JmjC domain-containing histone demethylation protein 2C antibody
    • Thryoid receptor interacting protein antibody
    • Thyroid receptor-interacting protein 8 antibody
    • TR-interacting protein 8 antibody
    • TRIP-8 antibody
    • TRIP8 antibody
    see all

Anti-JMJD1C antibody 图像

  • Immunofluorescence of JMJD1C in rat liver tissue with ab106457 at 20 ug/mL.

  • Lane 1 : Anti-JMJD1C antibody (ab106457) at 1 µg/ml
    Lane 2 : Anti-JMJD1C antibody (ab106457) at 2 µg/ml

    Lane 1 : Human liver tissue lysate
    Lane 2 : Human liver tissue lysate

    Lysates/proteins at 15 µg per lane.


    Predicted band size : 285 kDa
  • ab106457, at 2.5 ug/ml, staining JMJD1C in rat liver tissue.

Anti-JMJD1C antibody (ab106457)参考文献

ab106457 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your interest in Abcam's JMJD1C antibodies. I have confirmed that for both antibodies, the immunogen sequences are conserved in both variants, therefore the antibodies will react with variant 1 and 2 of JMJD1C. I hope this information...

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