概述

  • 产品名称Anti-JIP1抗体
    参阅全部 JIP1 一抗
  • 描述
    兔多克隆抗体to JIP1
  • 经测试应用适用于: WB, ELISA, IHC-P, ICC/IFmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Synthetic non-phosphopeptide derived from human JIP1 around the phosphorylation site of threonine 103 (G-D-TP-P-G).

  • 阳性对照
    • Human brain tissue. Extracts from HUVEC cells. 3T3 cells.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
  • 存储溶液Preservative: 0.02% Sodium Azide
    Constituents: 50% Glycerol, PBS (without Mg2+ and Ca2+), 150mM Sodium chloride, pH 7.4
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab78948 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Predicted molecular weight: 78 kDa.
ELISA 1/5000.
IHC-P 1/50 - 1/100.
ICC/IF 1/500 - 1/1000.

靶标

  • 相关性The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module and is required for JNK activation in response to excitotoxic stress. Cytoplasmic JIP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. It may also participate in ApoER2-specific reelin signaling and directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. It appears to have a role in cell signaling in mature and developing nerve terminals and may function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. It functions as an anti-apoptotic protein whose level seems to influence the beta-cell death or survival response.
  • 细胞定位Cytoplasmic. Accumulates in cell surface projections. Under certain stress conditions, translocates to the perinuclear region of neurons. In insulin-secreting cells, detected in both the cytoplasm and nucleus
  • 数据库链接
  • 别名
    • C jun amino terminal kinase interacting protein 1 antibody
    • IB 1 antibody
    • IB1 antibody
    • Islet brain 1 antibody
    • JIP 1 antibody
    • JNK interacting protein 1 antibody
    • JNK MAP kinase scaffold protein 1 antibody
    • MAPK8IP 1 antibody
    • MAPK8IP1 antibody
    • MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 antibody
    • Mitogen activated protein kinase 8 interacting protein 1 antibody
    • PRKM8 antibody
    • PRKM8 interacting protein antibody
    • PRKM8IP antibody
    see all

Anti-JIP1 antibody 图像

  • All lanes : Anti-JIP1 antibody (ab78948) at 1/500 dilution

    Lane 1 : Extracts from HUVEC cells
    Lane 2 : Extracts from HUVEC cells with immunising peptide at 10 µg

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 78 kDa
    Observed band size : 78 kDa
  • Immunohistochemistry analysis of paraffin-embedded human brain tissue using ab78948 at 1/50 dilution in the absence (left panel) or presence (right panel) of immunising peptide.
  • Immunofluorescence analysis of 3T3 cells using ab78948 at 1/500 dilution in the absence (left panel) or presence (right panel) of immunising peptide.

Anti-JIP1 antibody (ab78948)参考文献

ab78948 has not yet been referenced specifically in any publications.

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