概述

  • 产品名称Anti-Jarid2抗体
    参阅全部 Jarid2 一抗
  • 描述
    兔多克隆抗体to Jarid2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse
    预测可用于: Chicken
  • 免疫原

    Synthetic peptide corresponding to a region within internal sequence amino acids 201-250 (NASSSCQSTP RKGKTHKHVH NGHVFNGSSR SAREKEPAHK HRSKEATPGK) of Mouse Jarid2 (NP_068678).

  • 阳性对照
    • Mouse liver lysate

性能

应用

Our Abpromise guarantee covers the use of ab102571 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.25 µg/ml. Predicted molecular weight: 137 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling.
  • 组织特异性During embryogenesis, predominantly expressed in neurons and particularly in dorsal root ganglion cells.
  • 序列相似性Contains 1 ARID domain.
    Contains 1 JmjC domain.
    Contains 1 JmjN domain.
  • 结构域The ARID domain is required to target the PRC2 complex to its target genes.
    The GSGFP motif is required for the interaction with SUZ12.
  • 细胞定位Nucleus. Colocalizes with the PRC2 complex on chromatin.
  • Information by UniProt
  • 数据库链接
  • 别名
    • JARD2 antibody
    • JARD2_HUMAN antibody
    • JARID2 antibody
    • JMJ antibody
    • Jumonji AT rich interactive domain 2 antibody
    • Jumonji homolog antibody
    • Jumonji like protein antibody
    • Jumonji protein antibody
    • Jumonji/ARID domain containing protein 2 antibody
    • Jumonji/ARID domain-containing protein 2 antibody
    • Protein Jumonji antibody
    see all

Anti-Jarid2 antibody 图像

  • Anti-Jarid2 antibody (ab102571) at 0.25 µg/ml + Mouse liver lysate at 10 µg

    Predicted band size : 137 kDa

Anti-Jarid2 antibody (ab102571)参考文献

ab102571 has not yet been referenced specifically in any publications.

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