重组
RabMAb

Anti-JAK3抗体[EPR908(2)] (ab92595)

概述

  • 产品名称
    Anti-JAK3抗体[EPR908(2)]
    参阅全部 JAK3 一抗
  • 描述
    兔单克隆抗体[EPR908(2)] to JAK3
  • 经测试应用
    适用于: WB, ICCmore details
    不适用于: Flow Cyt or IHC-P
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide corresponding to residues on the N-terminus in Human JAK3

  • 阳性对照
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

性能

应用

Our Abpromise guarantee covers the use of ab92595 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
ICC
  • 应用说明
    ICC: 1/250 - 1/500.
    WB: 1/1000 - 1/10000. Predicted molecular weight: 125 kDa.

    Is unsuitable for Flow Cyt or IHC-P.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能
      Tyrosine kinase of the non-receptor type, involved in the interleukin-2 and interleukin-4 signaling pathway. Phosphorylates STAT6, IRS1, IRS2 and PI3K.
    • 组织特异性
      In NK cells and an NK-like cell line but not in resting T-cells or in other tissues. The S-form is more commonly seen in hematopoietic lines, whereas the B-form is detected in cells both of hematopoietic and epithelial origins.
    • 疾病相关
      Defects in JAK3 are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-negative (T(-)B(+)NK(-) SCID) [MIM:600802]. A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development.
    • 序列相似性
      Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
      Contains 1 FERM domain.
      Contains 1 protein kinase domain.
      Contains 1 SH2 domain.
    • 结构域
      Possesses two phosphotransferase domains. The second one probably contains the catalytic domain (By similarity), while the presence of slight differences suggest a different role for domain 1.
    • 翻译后修饰
      Tyrosine phosphorylated in response to IL-2 and IL-4.
    • 细胞定位
      Endomembrane system. Wholly intracellular, possibly membrane associated.
    • Information by UniProt
    • 数据库链接
    • 别名
      • EC 2.7.10.2 antibody
      • JAK 3 antibody
      • JAK L antibody
      • JAK-3 antibody
      • Jak3 antibody
      • JAK3 HUMAN antibody
      • JAK3_HUMAN antibody
      • JAKL antibody
      • Janus kinase 3 (a protein tyrosine kinase, leukocyte) antibody
      • Janus kinase 3 antibody
      • Janus Kinase3 antibody
      • L JAK antibody
      • L-JAK antibody
      • Leukocyte janus kinase antibody
      • LJAK antibody
      • Protein tyrosine kinase leukocyte antibody
      • Tyrosine protein kinase JAK3 antibody
      • Tyrosine-protein kinase JAK3 antibody
      see all

    图片

    • All lanes : Anti-JAK3 antibody [EPR908(2)] (ab92595) at 1/1000 dilution

      Lane 1 : IM-9 cell lysate
      Lane 2 : TF-1 cell lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      HRP labelled goat anti-rabbit at 1/2000 dilution

      Predicted band size : 125 kDa

    文献

    ab92595 has not yet been referenced specifically in any publications.

    客户评价及客户问答

    There are currently no Customer reviews or Questions for ab92595.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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