Anti-Jagged1抗体[MM0424-4A24] (ab89663)


  • 产品名称Anti-Jagged1抗体[MM0424-4A24]
    参阅全部 Jagged1 一抗
  • 描述
    小鼠单克隆抗体[MM0424-4A24] to Jagged1
  • 经测试应用适用于: WB, Flow Cytmore details
  • 种属反应性
    与反应: Rat, Human
  • 免疫原

    Recombinant full length Human Jagged1 protein.

  • 表位The epitope is extracellular.



Our Abpromise guarantee covers the use of ab89663 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Predicted molecular weight: 134 kDa.
Flow Cyt 1/50 - 1/200. Extracellular epitope -- no need to permeabilize.

ab18414-Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.


  • 功能Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro).
  • 组织特异性Widely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells.
  • 疾病相关Defects in JAG1 are the cause of Alagille syndrome type 1 (ALGS1) [MIM:118450]. Alagille syndrome is an autosomal dominant multisystem disorder defined clinically by hepatic bile duct paucity and cholestasis in association with cardiac, skeletal, and ophthalmologic manifestations. There are characteristic facial features and less frequent clinical involvement of the renal and vascular systems.
    Defects in JAG1 are a cause of tetralogy of Fallot (TOF) [MIM:187500]. TOF is a congenital heart anomaly which consists of pulmonary stenosis, ventricular septal defect, dextroposition of the aorta (aorta is on the right side instead of the left) and hypertrophy of the right ventricle. This condition results in a blue baby at birth due to inadequate oxygenation. Surgical correction is emergent.
  • 序列相似性Contains 1 DSL domain.
    Contains 15 EGF-like domains.
  • 发展阶段Expressed in 32-52 days embryos in the distal cardiac outflow tract and pulmonary artery, major arteries, portal vein, optic vesicle, otocyst, branchial arches, metanephros, pancreas, mesocardium, around the major bronchial branches, and in the neural tube.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • AGS antibody
    • AHD antibody
    • AWS antibody
    • CD 339 antibody
    • CD339 antibody
    • CD339 antigen antibody
    • Headturner antibody
    • hJ1 antibody
    • Htu antibody
    • Jag 1 antibody
    • Jag1 antibody
    • JAG1_HUMAN antibody
    • Jagged 1 antibody
    • Jagged1 (Alagille syndrome) antibody
    • Jagged1 antibody
    • JAGL1 antibody
    • MGC104644 antibody
    • OTTHUMP00000030278 antibody
    • Protein jagged-1 antibody
    • Ser 1 antibody
    • Ser1 antibody
    • Serrate 1 antibody
    • Slalom antibody
    see all

Anti-Jagged1 antibody [MM0424-4A24] (ab89663)参考文献

ab89663 has not yet been referenced specifically in any publications.

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Thank you for taking time to complete our questionnaire. I am sorry to hear that this antibody is not providing satisfactory results. I appreciate your patience while I was contacting the testing lab regarding your inquiry.

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Thank you for contacting Abcam regarding ab89663.

I am sorry that you have been experiencing difficulties with this antibody in FACS. The immunogen is extra cellular and it is not necessary to permeabilize cells for FC. Based on the pro...

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Thank you for your enquiry. This antibody has been used for Flow cytometry in human endothelial cells with 2.5ug of antibody for 1x10(6) cells.