概述

  • 产品名称Anti-Jagged 2抗体
    参阅全部 Jagged 2 一抗
  • 描述
    兔多克隆抗体to Jagged 2
  • 经测试应用适用于: ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide (10-30 aa in length) at the C-terminal of last 50 aa of human Jagged 2 conjugated to KLH

  • 阳性对照
    • Human breast carcinoma tissue.

性能

应用

Our Abpromise guarantee covers the use of ab60041 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/1000.
IHC-P 1/50 - 1/100.

靶标

  • 相关性Jagged 2 is a Notch ligand involved in the mediation of Notch signaling. Jagged 2 is expressed in heart, placenta and skeletal muscle and to a lesser extend in pancreas. Very low expression in brain, lung, liver and kidney. The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. Jagged 2 is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for Jagged 2.
  • 细胞定位Cell Membrane
  • 数据库链接
  • 别名
    • D12Ggc2e antibody
    • HJ 2 antibody
    • HJ2 antibody
    • JAG 2 antibody
    • JAG2 antibody
    • Jagged 2 precursor antibody
    • Jagged2 antibody
    • Protein jagged 2 antibody
    • SER2 antibody
    • Syndactylism antibody
    see all

Anti-Jagged 2 antibody 图像

  • ab60041 at 1/50-1/100 dilution staining Jagged 2 in Human breast carcinoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue. The primary antibody was peroxidase-conjugated to the secondary antibody, followed by AEC staining.

Anti-Jagged 2 antibody (ab60041)参考文献

This product has been referenced in:
  • Pietras A  et al. JAG2 Induction in Hypoxic Tumor Cells Alters Notch Signaling and Enhances Endothelial Cell Tube Formation. Mol Cancer Res 9:626-36 (2011). WB, IHC-P ; Human . Read more (PubMed: 21402725) »
  • Jung SG  et al. Prognostic significance of Notch 3 gene expression in ovarian serous carcinoma. Cancer Sci : (2010). IHC-P ; Human . Read more (PubMed: 20624166) »

See all 3 Publications for this product

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