This fast track antibody is not yet fully characterized. It is subject to these terms and conditions

概述

性能

应用

  • 应用说明WB: it was not possible to detect Jagged 2 in the lysates tested. This maybe due to low expression/abundance of Jagged 2 compounded by the fact that Jagged 2 expression is developmentally regulated and induced making it difficult to detect in whole tissue homogenates. In favour of the Jagged 2 antibody (ab10556), WB analysis shows relatively low background and minimal cross reactivity in various tissue lysates.

    Recommended dilutions
    Tested in peptide ELISA.
    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 相关性Jagged 2 is a Notch ligand involved in the mediation of Notch signaling. Jagged 2 is expressed in heart, placenta and skeletal muscle and to a lesser extend in pancreas. Very low expression in brain, lung, liver and kidney. The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. Jagged 2 is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for Jagged 2.
    • 细胞定位Cell Membrane
    • 数据库链接
    • 别名
      • D12Ggc2e antibody
      • HJ 2 antibody
      • HJ2 antibody
      • JAG 2 antibody
      • JAG2 antibody
      • Jagged 2 precursor antibody
      • Jagged2 antibody
      • Protein jagged 2 antibody
      • SER2 antibody
      • Syndactylism antibody
      see all

    Anti-Jagged 2 antibody 图像

    This Fast-Track antibody is not yet fully characterised. These images represent inconclusive preliminary data.

    • Western blot for Jagged 2 antibody (ab10556) at 1/500 tested on the following tissue lysates:

      Lane 1: Mouse Brain
      Lane 2: Mouse Lung
      Lane 3: Rat Brain
      Lane 4: Rat Lung
      Lane 5: Mouse Brain Day 0

      Secondary ab: Goat anti-rabbit IgG ab6721 (1/5000)
      Exposure time: 10 minutes
      Expected molecular weight: 130 kDa
      Cell lysates at 20µg per lane.

      NB: This image shows that is was not possible to detect Jagged 2 by WB in the lysates tested. This maybe due to low expression/abundance of Jagged 2 compounded by the fact that Jagged 2 expression is developmentally regulated and induced making it difficult to detect in whole tissue homogenates. In favour of the Jagged 2 antibody (ab10556), this WB shows relatively low background and minimal cross reactivity in tissue lysate.

    Anti-Jagged 2 antibody (ab10556)参考文献

    This product has been referenced in:
    • Iha H  et al. Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-kappaB activation. EMBO J : (2008). WB ; Mouse . Read more (PubMed: 18239685) »

    See 1 Publication for this product

    Product Wall

    Thank you for your patience. Regarding ab10580 (Goat polyclonal to Jagged 1), this is a polyclonal antibody therefore it is likely that several isotypes are present. However, this product has not been assayed to determine what isotypes are present....

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"