The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 1 µg/ml. Predicted molecular weight: 304 kDa. This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein.
Use at an assay dependent dilution.
功能Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
组织特异性Expressed in intestinal crypt and villus epithelial cells.
序列相似性Belongs to the InsP3 receptor family. Contains 5 MIR domains.
结构域The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.
翻译后修饰Phosphorylated on tyrosine residues. Phosphorylated by AKT1 on serine and/or threonine residues.