概述

  • 产品名称Anti-ITPR2抗体
    参阅全部 ITPR2 一抗
  • 描述
    兔多克隆抗体to ITPR2
  • 经测试应用适用于: ICC, IHC-Fr, ICC/IFmore details
    不适用于: WB
  • 种属反应性
    与反应: Mouse, Rat, Human, Amphibians, Salamander
    预测可用于: Cow
  • 免疫原

    Synthetic peptide corresponding to Rat ITPR2 aa 317-334.
    Sequence:

    ELNPDYRDAQNEGKTVRD


    (Peptide available as ab5842)

  • 阳性对照
    • Rat brain staining of the hippocampus, corpus collosum, and cerebellum.

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab5805 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC 1/100.
IHC-Fr 1/100.
ICC/IF Use at an assay dependent concentration. PubMed: 22285480
  • 应用说明Is unsuitable for WB.
  • 靶标

    • 功能Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA.
    • 组织特异性Isoform Short is found in skeletal muscle and heart.
    • 疾病相关Anhidrosis, isolated, with normal sweat glands
    • 序列相似性Belongs to the InsP3 receptor family.
      Contains 5 MIR domains.
    • 结构域The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.
    • 翻译后修饰Phosphorylation by cAMP-dependent PKA on Ser-937 increases calcium release.
    • 细胞定位Endoplasmic reticulum membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • 4 antibody
      • 5-trisphosphate receptor antibody
      • Inositol 1 4 5 trisphosphate receptor type 2 antibody
      • Inositol 1,4,5-trisphosphate receptor type 2 antibody
      • Inositol 145 trisphosphate receptor type 2 antibody
      • InsP3 R2 antibody
      • InsP3R2 antibody
      • IP3 R2 antibody
      • IP3 receptor antibody
      • IP3 receptor isoform 2 antibody
      • IP3R 2 antibody
      • IP3R2 antibody
      • ITPR 2 antibody
      • Itpr2 antibody
      • ITPR2_HUMAN antibody
      • Type 2 inositol 1 4 5 trisphosphate receptor antibody
      • Type 2 inositol 1 antibody
      • Type 2 inositol 145 trisphosphate receptor antibody
      • Type 2 InsP3 receptor antibody
      see all

    Anti-ITPR2 antibody 图像

    • Shows immunolocalization of IP3R-II in rat brain using ab5805.

    Anti-ITPR2 antibody (ab5805)参考文献

    This product has been referenced in:
    • Okamoto Y  et al. Arrhythmogenic coupling between the Na+ -Ca2+ exchanger and inositol 1,4,5-triphosphate receptor in rat pulmonary vein cardiomyocytes. J Mol Cell Cardiol 52:988-97 (2012). ICC/IF ; Rat . Read more (PubMed: 22285480) »

    See 1 Publication for this product

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