Anti-ITPR2抗体(ab104550)

概述

  • 产品名称Anti-ITPR2抗体
    参阅全部 ITPR2 一抗
  • 描述
    山羊多克隆抗体to ITPR2
  • 经测试应用适用于: ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Cow, Dog
  • 免疫原

    Synthetic peptide:

    C-PIEESNILSPVQD

    , corresponding to internal sequence amino acids 1152-1164 of Human ITPR2.

  • 阳性对照
    • Human heart, skin and kidney tissues.

性能

应用

Our Abpromise guarantee covers the use of ab104550 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/128000.
IHC-P Use a concentration of 3.75 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA.
  • 组织特异性Isoform Short is found in skeletal muscle and heart.
  • 疾病相关Anhidrosis, isolated, with normal sweat glands
  • 序列相似性Belongs to the InsP3 receptor family.
    Contains 5 MIR domains.
  • 结构域The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.
  • 翻译后修饰Phosphorylation by cAMP-dependent PKA on Ser-937 increases calcium release.
  • 细胞定位Endoplasmic reticulum membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 4 antibody
    • 5-trisphosphate receptor antibody
    • Inositol 1 4 5 trisphosphate receptor type 2 antibody
    • Inositol 1,4,5-trisphosphate receptor type 2 antibody
    • Inositol 145 trisphosphate receptor type 2 antibody
    • InsP3 R2 antibody
    • InsP3R2 antibody
    • IP3 R2 antibody
    • IP3 receptor antibody
    • IP3 receptor isoform 2 antibody
    • IP3R 2 antibody
    • IP3R2 antibody
    • ITPR 2 antibody
    • Itpr2 antibody
    • ITPR2_HUMAN antibody
    • Type 2 inositol 1 4 5 trisphosphate receptor antibody
    • Type 2 inositol 1 antibody
    • Type 2 inositol 145 trisphosphate receptor antibody
    • Type 2 InsP3 receptor antibody
    see all

Anti-ITPR2 antibody 图像

  • ab104550 at 3.75µg/ml staining ITPR2 in Human heart by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
  • ab104550 at 3.75µg/ml staining ITPR2 in Human skin by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
  • ab104550 at 3.75µg/ml staining ITPR2 in Human kidney by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-ITPR2 antibody (ab104550)参考文献

ab104550 has not yet been referenced specifically in any publications.

Product Wall

DISCOUNT CODE: 100%ABR-0000

Ablaufdatum: 01 Februar 2013

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