概述

  • 产品名称Anti-ITPK1抗体
    参阅全部 ITPK1 一抗
  • 描述
    兔多克隆抗体to ITPK1
  • 经测试应用适用于: WB, ICC/IFmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Pig
  • 免疫原

    Recombinant fragment, corresponding to a region within amino acids 171-405 of Human ITPK1 (AAH18192)

  • 阳性对照
    • 293T, A431, H1299, HeLaS3, HepG2, Molt-4, Raji and HeLa cells.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 10% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7.0
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

相关产品

应用

Our Abpromise guarantee covers the use of ab97447 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 46 kDa.
ICC/IF 1/100 - 1/200.

靶标

  • 功能Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetraphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain.
  • 组织特异性Expressed in brain > heart > skeletal muscle = kidney = pancreas = liver = placenta > lung. In brain, it is expressed in cerebellum, cerebral cortex, medulla, spinal cord, occipital lobe, frontal lobe, temporal lobe and putamen.
  • 序列相似性Belongs to the ITPK1 family.
    Contains 1 ATP-grasp domain.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 3 antibody
    • 4)P(3) 5/6-kinase antibody
    • 4-trisphosphate 5/6-kinase antibody
    • Inositol 1 3 4 triphosphate 5/6 kinase antibody
    • Inositol 1 3 4 trisphosphate 5/6 kinase antibody
    • Inositol 1 antibody
    • Inositol tetrakisphosphate 1 kinase antibody
    • Inositol triphosphate 5/6 kinase antibody
    • Inositol-tetrakisphosphate 1-kinase antibody
    • Inositol-triphosphate 5/6-kinase antibody
    • Ins(1 3 4)P(3) 5/6 kinase antibody
    • Ins(1 antibody
    • ITPK 1 antibody
    • itpk1 antibody
    • ITPK1_HUMAN antibody
    • ITRPK 1 antibody
    • ITRPK1 antibody
    see all

Anti-ITPK1 antibody 图像

  • Anti-ITPK1 antibody (ab97447) at 1/1000 dilution + A431 whole cell lysate at 30 µg

    Predicted band size : 46 kDa
  • Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using ab97447 at 1/200 dilution (1) and merged with DNA probe (2).

Anti-ITPK1 antibody (ab97447)参考文献

ab97447 has not yet been referenced specifically in any publications.

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