概述

  • 产品名称Anti-ITM2B抗体
    参阅全部 ITM2B 一抗
  • 描述
    兔多克隆抗体to ITM2B
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Full length Human ITM2B (AAH16148.1; amino acids 1-266).

  • 阳性对照
    • Mouse liver lysate; ITM2B transfected 293T cell lysate

性能

应用

Our Abpromise guarantee covers the use of ab103474 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 30 kDa.

靶标

  • 功能Functions as a protease inhibitor. Plays a role in APP processing regulating the physiological production of the beta amyloid peptide. Restricts docking of gamma-secretase to APP and access of alpha- and beta-secretase to their cleavage APP sequence.
  • 组织特异性Expressed in brain and in other tissues.
  • 疾病相关Defects in ITM2B are a cause of cerebral amyloid angiopathy ITM2B-related type 1 (CAA-ITM2B1) [MIM:176500]. A disorder characterized by amyloid deposition in the walls of cerebral blood vessels and neurodegeneration in the central nervous system. Cerebral amyloid angiopathy, non-neuritic and perivascular plaques and neurofibrillary tangles are the predominant pathological lesions. Clinical features include progressive mental deterioration, spasticity and muscular rigidity.
    Defects in ITM2B are a cause of cerebral amyloid angiopathy ITM2B-related type 2 (CAA-ITM2B2) [MIM:117300]; also known as heredopathia ophthalmo-oto-encephalica. A disorder characterized by amyloid deposition in the walls of the blood vessels of the cerebrum, choroid plexus, cerebellum, spinal cord and retina. Plaques and neurofibrillary tangles are observed in the hippocampus. Clinical features include progressive ataxia, dementia, cataracts and deafness.
  • 序列相似性Belongs to the ITM2 family.
    Contains 1 BRICHOS domain.
  • 翻译后修饰The C-terminal part of the ectodomain is processed by furin and related proteases producing a secreted peptide of 4 to 5 kDa. For the ABRI and ADAN variants the C-terminal secreted peptide is larger and may produce amyloid fibrils responsible for neuronal dysfunction and dementia. The remaining part of the ectodomain containing the BRICHOS domain is cleaved by ADAM10 and is secreted as a peptide of 25 kDa. The membrane-bound N-terminal fragment (NTF) of 22 kDa is further proteolytically processed by SPPL2A and SPPL2B through regulated intramembrane proteolysis producing a secreted peptide (BRI2C) and an intracellular domain (ICD) released in the cytosol.
  • 细胞定位Golgi apparatus membrane. Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ABRI antibody
    • ABri/ADan amyloid peptide antibody
    • BRI 2 antibody
    • BRI antibody
    • BRI2 antibody
    • BRICD 2B antibody
    • BRICD2B antibody
    • BRICHOS domain containing 2B antibody
    • E25B antibody
    • E3 16 antibody
    • E3-16 antibody
    • FBD antibody
    • Integral membrane protein 2B antibody
    • ITM 2B antibody
    • ITM2B antibody
    • ITM2B_HUMAN antibody
    • Protein E25B antibody
    • Transmembrane protein BRI antibody
    see all

Anti-ITM2B antibody 图像

  • Anti-ITM2B antibody (ab103474) at 5 µg/ml + Mouse liver lysate at 50 µg

    Predicted band size : 30 kDa
  • All lanes : Anti-ITM2B antibody (ab103474) at 5 µg/ml

    Lane 1 : ITM2B transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 30 kDa

Anti-ITM2B antibody (ab103474)参考文献

ab103474 has not yet been referenced specifically in any publications.

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