概述

  • 产品名称Anti-ITGB3BP抗体
    参阅全部 ITGB3BP 一抗
  • 描述
    兔多克隆抗体to ITGB3BP
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 35-84 (TGTCQMSLFA SPTSSEEQKH RNGLSNEKRK KLNHPSLTES KESTTKDNDE), of Human ITGB3BP (NP_055103)

  • 阳性对照
    • MCF7 cell lysate

应用

Our Abpromise guarantee covers the use of ab82764 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 20 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
ELISA Use at an assay dependent concentration.

Titre using peptide based assay: 1/62500.

靶标

  • 相关性ITGB3BP is a transcriptional coregulator that has both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. ITGB3BP also acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit. ITGB3BP induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization. It also acts as a component of the CENPH-CENPI centromeric complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation.
  • 细胞定位Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Cytoplasm. Isoform 4: Cytoplasm. Note=Localizes in the centromeres. Isoform 3 is predominantly nuclear and weakly cytoplasmic.
  • 数据库链接
  • 别名
    • Beta 3 endonexin antibody
    • Beta3 endonexin antibody
    • Beta3 endonexin long form antibody
    • CENP R antibody
    • CENPR antibody
    • CENPR_HUMAN antibody
    • Centromere protein R antibody
    • endonexin, Beta-3 antibody
    • HSU37139 antibody
    • Integrin beta 3 binding protein (beta3-endonexin) antibody
    • Integrin beta 3 binding protein antibody
    • NRIF 3 antibody
    • NRIF3 antibody
    • Nuclear receptor interacting factor 3 antibody
    • TAP 20 antibody
    • TAP20 antibody
    see all

Anti-ITGB3BP antibody 图像

  • Anti-ITGB3BP antibody (ab82764) at 1 µg/ml + MCF7 cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 20 kDa
    Observed band size : 23 kDa (why is the actual band size different from the predicted?)
    Additional bands at : >90 kDa. We are unsure as to the identity of these extra bands.

Anti-ITGB3BP antibody (ab82764)参考文献

ab82764 has not yet been referenced specifically in any publications.

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