概述

  • 产品名称
  • 描述
    小鼠单克隆抗体to ITGA8
  • 经测试应用
    适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Recombinant fragment
    预测可用于: Human
  • 免疫原

    Recombinant fragment: SDTILEVGWP FSARDEFLLY IFHIQTLGPL QCQPNPNINP QDIKPAASPE DTPELSAFLR NSTIPHLVRK RDVHVVEFHR QSPAKILNCT NIECLQISCA , corresponding to amino acids 836-936 of Human ITGA8

  • 常规说明

    Abcam is committed to meeting high standards of ethical manufacturing and as such, we will be discontinuing this product, which has been generated by the ascites method, within the next year. We are sorry for any inconvenience this may cause. If you would like help finding an alternative product, please do not hesitate to contact our scientific support team.

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液
    Preservative: None
    PBS, pH 7.2
  • Concentration information loading...
  • 纯度
    Protein G purified
  • 克隆
    单克隆
  • 同种型
    IgG2b
  • 轻链类型
    kappa
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab56355 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 5 µg/ml. This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.
IHC-P Use at an assay dependent concentration. PubMed: 20435685

靶标

  • 功能
    Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons.
  • 组织特异性
    Expressed in mesenchymal cells, including alveolar myofibroblasts, kidney mesangial cells and hepatic stellar cells and vascular and visceral smooth muscle (at protein level).
  • 序列相似性
    Belongs to the integrin alpha chain family.
    Contains 7 FG-GAP repeats.
  • 细胞定位
    Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Integrin alpha 8 antibody
    • Integrin alpha-8 heavy chain antibody
    • Integrin alpha-8 light chain antibody
    • ITA8_HUMAN antibody
    • ITGA 8 antibody
    • ITGA8 antibody
    see all

图片

  • Western blot against tagged recombinant protein immunogen using ab56355 ITGA8 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

文献

This product has been referenced in:
  • Frith JE  et al. Tailored integrin-extracellular matrix interactions to direct human mesenchymal stem cell differentiation. Stem Cells Dev 21:2442-56 (2012). Read more (PubMed: 22455378) »
  • Singh SR  et al. Can lineage-specific markers be identified to characterize mesenchyme-derived cell populations in the human airways? Am J Physiol Lung Cell Mol Physiol 299:L169-83 (2010). IHC-P ; Human . Read more (PubMed: 20435685) »

See all 2 Publications for this product

客户评价及客户问答

There are currently no Customer reviews or Questions for ab56355.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

注册