Anti-Isocitrate dehydrogenase抗体(ab36329)

概述

  • 产品名称Anti-Isocitrate dehydrogenase抗体
    参阅全部 Isocitrate dehydrogenase 一抗
  • 描述
    兔多克隆抗体to Isocitrate dehydrogenase
  • 经测试应用适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Mouse
  • 免疫原

    Full length native protein purified from porcine heart

  • 阳性对照
    • WB: mouse tissues including spleen, kidney, lung, heart, liver and brain.

性能

应用

Our Abpromise guarantee covers the use of ab36329 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/400 - 1/1600.
WB 1/500 - 1/2000. Detects a band of approximately 40 kDa (predicted molecular weight: 47 kDa).

靶标

  • 疾病相关Glioma
    Genetic variations are associated with cartilaginous tumors such as enchondroma or chondrosarcoma. Mutations of Arg-132 to Cys, Gly or His abolish the conversion of isocitrate to alpha-ketoglutarate. Instead, alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate.
  • 序列相似性Belongs to the isocitrate and isopropylmalate dehydrogenases family.
  • 翻译后修饰Acetylation at Lys-374 dramatically reduces catalytic activity.
  • 细胞定位Cytoplasm. Peroxisome.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Cytosolic NADP isocitrate dehydrogenase antibody
    • Cytosolic NADP-isocitrate dehydrogenase antibody
    • Epididymis luminal protein 216 antibody
    • Epididymis secretory protein Li 26 antibody
    • HEL-216 antibody
    • HEL-S-26 antibody
    • ICDH antibody
    • IDCD antibody
    • IDH antibody
    • IDH1 antibody
    • IDHC_HUMAN antibody
    • IDP antibody
    • IDPC antibody
    • Isocitrate dehydrogenase [NADP] cytoplasmic antibody
    • Isocitrate dehydrogenase 1 (NADP+) soluble antibody
    • NADP dependent isocitrate dehydrogenase cytosolic antibody
    • NADP dependent isocitrate dehydrogenase peroxisomal antibody
    • NADP(+)-specific ICDH antibody
    • Oxalosuccinate decarboxylase antibody
    • PICD antibody
    see all

Anti-Isocitrate dehydrogenase antibody 图像

  • Titration curve of ab36329, rabbit antibody to Isocitrate dehyrogenase (ICDH). Plates coated with 400 ng/well of native Isocitrate Dedydrogenease derived from pig heart.

Anti-Isocitrate dehydrogenase antibody (ab36329)参考文献

This product has been referenced in:
  • Bellingham M  et al. Exposure to chemical cocktails before or after conception - the effect of timing on ovarian development. Mol Cell Endocrinol 376:156-72 (2013). IHC . Read more (PubMed: 23791816) »
  • Mancone C  et al. Proteomic analysis reveals a major role for contact inhibition in the terminal differentiation of hepatocytes. J Hepatol 52:234-43 (2010). WB ; Mouse . Read more (PubMed: 20031246) »

See all 5 Publications for this product

Product Wall

Thank you for your enquiry. I have conferred with out laboratory and it seems that we have not tested the cross reactivity with all isoforms of the antibody, so unfortunately we do not know if ab36329 is Isocitrate dehydrogenase I or not. I am...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"