The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 0.3 - 1 µg/ml. Predicted molecular weight: 39 kDa.
疾病相关Glioma Genetic variations are associated with cartilaginous tumors such as enchondroma or chondrosarcoma. Mutations of Arg-132 to Cys, Gly or His abolish the conversion of isocitrate to alpha-ketoglutarate. Instead, alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate.
序列相似性Belongs to the isocitrate and isopropylmalate dehydrogenases family.
翻译后修饰Acetylation at Lys-374 dramatically reduces catalytic activity.