概述

  • 产品名称Anti-ISCU抗体
    参阅全部 ISCU 一抗
  • 描述
    兔多克隆抗体to ISCU
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Rat
    预测可用于: Mouse, Rabbit, Goat, Horse, Guinea pig, Cow, Cat, Dog, Zebrafish
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 14-63 (SALLLRSPRL PARELSAPAR LYHKKVVDHY ENPRNVGSLD KTSKNVGTGL), of Rat ISCU (NP_001099406)

  • 阳性对照
    • Rat lung lysate

性能

应用

Our Abpromise guarantee covers the use of ab113812 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 18 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Involved in the assembly or repair of the [Fe-S] clusters present in iron-sulfur proteins. Binds iron.
  • 组织特异性Detected in heart, liver, skeletal muscle, brain, pancreas, kidney, lung and placenta.
  • 疾病相关Defects in ISCU are the cause of myopathy with exercise intolerance Swedish type (MEIS) [MIM:255125]; also known as myopathy with deficiency of succinate dehydrogenase and aconitase or myoglobinuria due to abnormal glycolysis or hereditary myopathy with lactic acidosis (HML). This autosomal recessive metabolic disease is characterized by lifelong severe exercise intolerance, in which minor exertion causes fatigue of active muscles, shortness of breath, and cardiac palpitations in association with lactic acidosis. The biochemical phenotype is characterized by a deficiency in mitochondrial iron-sulfur proteins and impaired muscle oxidative metabolism.
  • 序列相似性Belongs to the nifU family.
  • 细胞定位Cytoplasm. Nucleus and Mitochondrion.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 2310020H20Rik antibody
    • HML antibody
    • hnifU antibody
    • Iron sulfur cluster assembly enzyme ISCU mitochondrial antibody
    • Iron sulfur cluster scaffold homolog (E. coli) antibody
    • Iron sulfur cluster scaffold homolog antibody
    • Iron-sulfur cluster assembly enzyme ISCU antibody
    • Iscu antibody
    • IscU iron sulfur cluster scaffold homolog antibody
    • ISCU_HUMAN antibody
    • ISU2 antibody
    • MGC74517 antibody
    • mitochondrial antibody
    • NIFU antibody
    • NifU like N terminal domain containing antibody
    • NifU like N terminal domain containing protein antibody
    • NifU like protein antibody
    • NifU-like N-terminal domain-containing protein antibody
    • NifU-like protein antibody
    • NIFUN antibody
    • Nitrogen fixation cluster like antibody
    • OTTHUMP00000238760 antibody
    • OTTHUMP00000238761 antibody
    • OTTHUMP00000238762 antibody
    • OTTHUMP00000238764 antibody
    • OTTHUMP00000238765 antibody
    see all

Anti-ISCU antibody 图像

  • Anti-ISCU antibody (ab113812) at 1 µg/ml + rat lung lysate at 10 µg

    Predicted band size : 18 kDa

Anti-ISCU antibody (ab113812)参考文献

ab113812 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab113812.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"