Anti-IRS1抗体, prediluted (ab53649)

概述

  • 产品名称Anti-IRS1抗体, prediluted
    参阅全部 IRS1 一抗
  • 描述
    兔多克隆抗体to IRS1, prediluted
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Chicken
  • 免疫原

    Synthetic peptide:

    SEDLSAYASISFQKQPEDRQ

    , corresponding to amino acids 1223-1242 of Human IRS1

  • 阳性对照
    • Human colon carcinoma tissue

性能

应用

Our Abpromise guarantee covers the use of ab53649 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
  • 应用说明IHC-P: Ready-to-use for 30 min at RT. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit.
    • 疾病相关Polymorphisms in IRS1 may be involved in the etiology of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:125853].
    • 序列相似性Contains 1 IRS-type PTB domain.
      Contains 1 PH domain.
    • 翻译后修饰Serine phosphorylation of IRS1 is a mechanism for insulin resistance. Ser-312 phosphorylation inhibits insulin action through disruption of IRS1 interaction with the insulin receptor.
      Phosphorylation of Tyr-896 is required for GRB2-binding.
    • Information by UniProt
    • 数据库链接
    • 别名
      • HIRS 1 antibody
      • HIRS1 antibody
      • Insulin receptor substrate 1 antibody
      • IRS 1 antibody
      • IRS-1 antibody
      • IRS1 antibody
      • IRS1_HUMAN antibody
      • OTTHUMP00000164234 antibody
      see all

    Anti-IRS1 antibody, prediluted 图像

    • ab53649, used neat, staining Human IRS1 in Colon Carcinoma, using Immunohistochemistry, Formalin Fixed Paraffin Embedded tissue.

    Anti-IRS1 antibody, prediluted (ab53649)参考文献

    ab53649 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"