概述

  • 产品名称Anti-IRS1抗体
    参阅全部 IRS1 一抗
  • 描述
    兔多克隆抗体to IRS1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse
    预测可用于: Rat, Chicken, Human, Xenopus laevis, African Green Monkey
  • 免疫原

    Synthetic peptide corresponding to Human IRS1 aa 631-646.
    Sequence:

    DYMPMSPKSVSAPQQI


    (Peptide available as ab41777)

  • 阳性对照
    • By Western blot, this antibody detects a ~170 kDa protein representing IRS1 from 3T3 L1 cell extract.

性能

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应用

Our Abpromise guarantee covers the use of ab5604 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 2 µg/ml. Detects a band of approximately 170 kDa (predicted molecular weight: 149 kDa).Can be blocked with Human IRS1 peptide (ab41777).

靶标

  • 功能May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit.
  • 疾病相关Polymorphisms in IRS1 may be involved in the etiology of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:125853].
  • 序列相似性Contains 1 IRS-type PTB domain.
    Contains 1 PH domain.
  • 翻译后修饰Serine phosphorylation of IRS1 is a mechanism for insulin resistance. Ser-312 phosphorylation inhibits insulin action through disruption of IRS1 interaction with the insulin receptor.
    Phosphorylation of Tyr-896 is required for GRB2-binding.
  • Information by UniProt
  • 数据库链接
  • 别名
    • HIRS 1 antibody
    • HIRS1 antibody
    • Insulin receptor substrate 1 antibody
    • IRS 1 antibody
    • IRS-1 antibody
    • IRS1 antibody
    • IRS1_HUMAN antibody
    • OTTHUMP00000164234 antibody
    see all

Anti-IRS1 antibody (ab5604)参考文献

ab5604 has not yet been referenced specifically in any publications.

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