概述

  • 产品名称Anti-IRS1抗体
    参阅全部 IRS1 一抗
  • 描述
    兔多克隆抗体to IRS1
  • 经测试应用适用于: ELISA, IHC-P, ICC/IFmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region from the internal domain of Human IRS1 (NP_005535.1).

  • 阳性对照
    • Human Adrenal (medulla) and Intestine (epithelium) tissues; COS7 cells.

性能

应用

Our Abpromise guarantee covers the use of ab118846 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA Use at an assay dependent concentration.
IHC-P Use a concentration of 10 µg/ml.
ICC/IF 1/100 - 1/500.

靶标

  • 功能May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit.
  • 疾病相关Polymorphisms in IRS1 may be involved in the etiology of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:125853].
  • 序列相似性Contains 1 IRS-type PTB domain.
    Contains 1 PH domain.
  • 翻译后修饰Serine phosphorylation of IRS1 is a mechanism for insulin resistance. Ser-312 phosphorylation inhibits insulin action through disruption of IRS1 interaction with the insulin receptor.
    Phosphorylation of Tyr-896 is required for GRB2-binding.
  • Information by UniProt
  • 数据库链接
  • 别名
    • HIRS 1 antibody
    • HIRS1 antibody
    • Insulin receptor substrate 1 antibody
    • IRS 1 antibody
    • IRS-1 antibody
    • IRS1 antibody
    • IRS1_HUMAN antibody
    • OTTHUMP00000164234 antibody
    see all

Anti-IRS1 antibody 图像

  • ab118846, at 10 µg/ml, staining IRS1 in Formalin-fixed, Paraffin-embedded Human Adrenal (medulla) tissue by Immunohistochemistry.
  • ab118846, at 10 µg/ml, staining IRS1 in Formalin-fixed, Paraffin-embedded Human Intestine (epithelium) tissue by Immunohistochemistry.
  • Immunofluorescence analysis of COS7 cells, using ab118846 at a dilution of 1/100. The image on the right is treated with the synthesized peptide.

Anti-IRS1 antibody (ab118846)参考文献

ab118846 has not yet been referenced specifically in any publications.

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