概述

描述

  • 性质Synthetic

相关产品

技术指标

Our Abpromise guarantee covers the use of ab115829 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-IRGM antibody (ab69495)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: 0.02% Sodium azide
    Constituents: PBS, 0.1% Bovine serum

常规信息

  • 别名
    • IFI1
    • Iigp3
    • Iipg3
    • Immunity related GTPase family M protein 1
    • Immunity related GTPase family, M
    • Immunity-related GTPase family M protein
    • Immunity-related GTPase family M protein 1
    • Interferon inducible protein 1
    • Interferon-inducible protein 1
    • Irgm
    • IRGM_HUMAN
    • IRGM1
    • LPS-stimulated RAW 264.7 macrophage protein 47 homolog
    • LRG 47
    • LRG-47
    • LRG-47-like protein
    • LRG47
    • MGC149263
    • MGC149264
    see all
  • 功能Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility.
  • 组织特异性Widely expressed (at protein level). Expressed in several tissues including colon, small bowel and peripheral blood leukocytes.
  • 疾病相关Defects in IRGM are the cause of susceptibility to inflammatory bowel disease type 19 (IBD19) [MIM:612278]. A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.
  • 序列相似性Belongs to the interferon-inducible GTPase family.
  • 细胞定位Golgi apparatus membrane. Cell membrane. Cytoplasmic vesicle > phagosome membrane. Cytoplasmic vesicle > autophagosome membrane. Cell projection > phagocytic cup. Behaves like an integral membrane protein (By similarity). Recruited to the plasma membrane around forming phagocytic cups, it remains associated with maturing autophagosomes (By similarity). Preferentially associated with cis- and medial-Golgi.
  • Information by UniProt

IRGM peptide (ab115829)参考文献

ab115829 has not yet been referenced specifically in any publications.

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