概述

  • 产品名称
    Anti-IRF7抗体[3D9]
    参阅全部 IRF7 一抗
  • 描述
    小鼠单克隆抗体[3D9] to IRF7
  • 经测试应用
    适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment, corresponding to N terminal amino acids 1-150 of Human IRF7 purified from E.coli.

  • 阳性对照
    • Jurkat cell lysates.

性能

应用

Our Abpromise guarantee covers the use of ab70069 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/2000. Detects a band of approximately 54 kDa (predicted molecular weight: 54 kDa).
ELISA Use at an assay dependent dilution.

靶标

  • 功能
    Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) in IFN promoters and in the Q promoter (Qp) of EBV nuclear antigen 1 (EBNA1). Functions as a molecular switch for antiviral activity. Activated by phosphorylation in response to infection. Activation leads to nuclear retention, DNA binding, and derepression of transactivation ability.
  • 组织特异性
    Expressed predominantly in spleen, thymus and peripheral blood leukocytes.
  • 序列相似性
    Belongs to the IRF family.
    Contains 1 IRF tryptophan pentad repeat DNA-binding domain.
  • 翻译后修饰
    In response to a viral infection, phosphorylated on the C-terminal serine cluster. Phosphorylation, and subsequent activation is inhibited by vaccinia virus protein E3.
    TRAF6-mediated ubiquitination is required for IRF7 activation.
  • 细胞定位
    Nucleus. Cytoplasm. The phosphorylated and active form accumulates selectively in the nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • IMD39 antibody
    • Interferon regulatory factor 7 antibody
    • Interferon regulatory factor 7H antibody
    • IRF 7 antibody
    • IRF 7A antibody
    • IRF 7H antibody
    • IRF-7 antibody
    • IRF7 antibody
    • IRF7_HUMAN antibody
    • IRF7A antibody
    • IRF7B antibody
    • IRF7C antibody
    • IRF7H antibody
    see all

图片

  • Anti-IRF7 antibody [3D9] (ab70069) at 1/1000 dilution + Jurkat cell lysates at 40 µg

    Secondary
    Goat anti-mouse secondary antibody conjugated to HRP
    Developed using the ECL technique

    Predicted band size : 54 kDa
    Observed band size : 54 kDa

实验方案

文献

ab70069 has not yet been referenced specifically in any publications.

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