概述
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产品名称Anti-IRE1 (phospho S724)抗体(Biotin)
参阅全部 IRE1 一抗 -
描述兔多克隆抗体to IRE1 (phospho S724) (Biotin)
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偶联物Biotin
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经测试应用适用于: WBmore details
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种属反应性与反应: Mouse, Rat, Human
不与反应: Monkey -
免疫原
Synthetic peptide surrounding the phosphorylated serine 724 of human IRE1.
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阳性对照
- Glucose treated pancreatic islets and endogenous protein of pancreatic beta cells and insuli. COS-7 expressing wild-type IRE1. Min6 cells treated with glucose.
性能
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形式Liquid
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存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
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存储溶液Preservative: None
Constituents: 30% Glycerol, PBS -
Concentration information loading... -
纯度Immunogen affinity purified
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克隆多克隆
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同种型IgG
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研究领域
相关产品
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Compatible Secondaries
应用
Our Abpromise guarantee covers the use of ab81936 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB | 1/1000. Detects a band of approximately 110 kDa (predicted molecular weight: 110 kDa). |
靶标
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功能Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.
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组织特异性Ubiquitously expressed. High levels observed in pancreatic tissue.
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序列相似性Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Contains 1 KEN domain.
Contains 1 protein kinase domain. -
翻译后修饰Autophosphorylated.
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细胞定位Endoplasmic reticulum membrane.
- Information by UniProt
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数据库链接
- Entrez Gene: 10595 Human
- Entrez Gene: 2081 Human
- Entrez Gene: 78943 Mouse
- Entrez Gene: 498013 Rat
- Omim: 604033 Human
- SwissProt: O75460 Human
- SwissProt: Q76MJ5 Human
- SwissProt: Q9EQY0 Mouse
see all -
别名
- Endoplasmic reticulum (ER) to nucleus signalling 1 antibody
- Endoplasmic reticulum to nucleus signaling 1 antibody
- Endoplasmic reticulum-to-nucleus signaling 1 antibody
see all
Anti-IRE1 (phospho S724) antibody (Biotin) (ab81936)参考文献
ab81936 has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"