概述

  • 产品名称Anti-IRAK4抗体
    参阅全部 IRAK4 一抗
  • 描述
    兔多克隆抗体to IRAK4
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Sheep, Human
  • 免疫原

    Synthetic peptide, corresponding to amino acids 38-50 (IKKPSGDDRYNQ) and 120-136 (VAQTHGPCQEKDRTSVM) of mouse IRAK4.

  • 阳性对照
    • Tested with NIH 3T3 cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab13685 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/2000. Detects a band of approximately 51 kDa.

靶标

  • 功能Required for the efficient recruitment of IRAK1 to the IL-1 receptor complex following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. Phosphorylates IRAK1.
  • 疾病相关Defects in IRAK4 are the cause of recurrent isolated invasive pneumococcal disease type 1 (IPD1) [MIM:610799]. Recurrent invasive pneumococcal disease (IPD) is defined as two episodes of IPD occurring at least 1 month apart, whether caused by the same or different serotypes or strains. Recurrent IPD occurs in at least 2% of patients in most series, making IPD the most important known risk factor for subsequent IPD.
    Defects in IRAK4 are the cause of IRAK4 deficiency (IRAK4D) [MIM:607676]. IRAK4 deficiency causes extracellular pyogenic bacterial and fungal infections in otherwise healthy children.
  • 序列相似性Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
    Contains 1 death domain.
    Contains 1 protein kinase domain.
  • Information by UniProt
  • 数据库链接
  • 别名
    • IL-1 receptor-associated kinase 4 antibody
    • Interleukin 1 receptor associated kinase 4 mutant form 1 antibody
    • Interleukin-1 receptor-associated kinase 4 antibody
    • Interleukin1 receptor associated kinase 4 antibody
    • IPD1 antibody
    • IRAK 4 antibody
    • IRAK-4 antibody
    • IRAK4 antibody
    • IRAK4 mutated form 1 antibody
    • IRAK4_HUMAN antibody
    • LOC 51135 antibody
    • NY REN 64 antibody
    • NY REN 64 antigen antibody
    • NY-REN-64 antibody
    • REN64 antibody
    • Renal carcinoma antigen NY-REN-64 antibody
    see all

Anti-IRAK4 antibody 图像

  • Western blot analysis of IRAK-4 in 30 ugs of NIH 3T3 cell lysate using ab13685 at 1:500 dilution.

Anti-IRAK4 antibody (ab13685)参考文献

This product has been referenced in:
  • Kallapur SG  et al. Pulmonary and Systemic Endotoxin Tolerance in Preterm Fetal Sheep Exposed to Chorioamnionitis. J Immunol 179:8491-8499 (2007). WB ; Sheep . Read more (PubMed: 18056396) »
  • Liu G  et al. Variant IL-1 receptor-associated kinase-1 mediates increased NF-kappa B activity. J Immunol 179:4125-34 (2007). WB ; Human . Read more (PubMed: 17785851) »

See all 2 Publications for this product

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