概述

  • 产品名称
  • 描述
    兔多克隆抗体to IQSEC1
  • 经测试应用
    适用于: IHC-P, ICC/IFmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    antigen sequence: PSSETGTSLD SPSAYPQGPL VPGSSLSPDH YEHTSVGAYG LYSGPPGQQQ RTRRPKLQHS TSILRKQAE, corresponding to N terminal amino acids 28-96 of Human IQSEC1 protein (UniProt ID: Q6DN90).

  • 阳性对照
    • Human skin tissue; Human cell line A431

性能

应用

Our Abpromise guarantee covers the use of ab122442 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC/IF Use a concentration of 1 - 4 µg/ml.

靶标

  • 功能
    In addition to accelerate GTP gamma S binding by ARFs of all three classes, it appears to function preferentially as a guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin.
  • 组织特异性
    Expressed in brain, ovary, heart, lung, liver, kidney and leukocytes. Moderate expression was also detected in lung, skeletal muscle, placenta, small intestine, pancreas, spleen and testis.
  • 序列相似性
    Belongs to the BRAG family.
    Contains 1 IQ domain.
    Contains 1 PH domain.
    Contains 1 SEC7 domain.
  • 细胞定位
    Cytoplasm. Nucleus. At steady state, may be preferentially cytosolic.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ADP-ribosylation factors guanine nucleotide-exchange protein 100 antibody
    • ADP-ribosylation factors guanine nucleotide-exchange protein 2 antibody
    • ARF GEP100 antibody
    • ARFGEP100 antibody
    • BRAG2 antibody
    • Brefeldin A resistant ARF GEF2 antibody
    • Brefeldin-resistant Arf-GEF 2 protein antibody
    • GEP100 antibody
    • IQ motif and Sec7 domain 1 antibody
    • IQ motif and SEC7 domain-containing protein 1 antibody
    • IQEC1_HUMAN antibody
    • Iqsec1 antibody
    • Kiaa0763 antibody
    see all

Anti-IQSEC1 antibody 图像

  • ab122442, at a 1/50 dilution, staining IQSEC1 in paraffin embedded Human skin tissue by Immunohistochemistry.
  • ab122442, at 4 µg/ml, staining IQSEC1 in Human A431 cell line, in green, by Immunoflouroscence.
    Fixation/Permeabilization: PFA/Triton X-100.

Anti-IQSEC1 antibody (ab122442)参考文献

This product has been referenced in:
  • Humphreys D  et al. Arf6 coordinates actin assembly through the WAVE complex, a mechanism usurped by Salmonella to invade host cells. Proc Natl Acad Sci U S A 110:16880-5 (2013). WB ; Human coronavirus . Read more (PubMed: 24085844) »

See 1 Publication for this product

Product Wall

There are currently no Abreviews or Questions for ab122442.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

注册