Anti-IPO11抗体- N-terminal (ab93475)

概述

  • 产品名称
    Anti-IPO11抗体- N-terminal
    参阅全部 IPO11 一抗
  • 描述
    兔多克隆抗体to IPO11 - N-terminal
  • 经测试应用
    适用于: IHC-P, Flow Cyt, WB, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide selected from the N terminal region of Human IPO11 conjugated to KLH (NP_057422.3).

  • 阳性对照
    • Hela cell line lysates

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液
    Preservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 纯化说明
    ab93475 is purified through a protein A column, followed by peptide affinity purification.
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab93475 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/50.
Flow Cyt 1/10.

ab171870-Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody.

WB 1/100 - 1/500. Predicted molecular weight: 113 kDa.
ELISA 1/1000.

靶标

  • 功能
    Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBE2E3, and of RPL12.
  • 序列相似性
    Belongs to the importin beta family.
    Contains 15 HEAT repeats.
    Contains 1 importin N-terminal domain.
  • 细胞定位
    Cytoplasm. Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Imp11 antibody
    • Importin 11 antibody
    • Importin-11 antibody
    • IPO11 antibody
    • IPO11_HUMAN antibody
    • Ran binding protein 11 antibody
    • Ran-binding protein 11 antibody
    • RanBP11 antibody
    • SLRN antibody
    • Synleurin antibody
    see all

图片

  • Immunohistochemistry of Formalin-fixed and paraffin embedded human testis tissue labeling IPO11 with ab93475 at 1:50 dilution 

     

  • Flow cytometry analysis of HeLa cells labeling IPO11 with ab93475 at 1:10 dilution.

     

  • Anti-IPO11 antibody - N-terminal (ab93475) at 1/100 dilution + HeLa cell line lysates at 35 µg

    Predicted band size : 113 kDa

文献

ab93475 has not yet been referenced specifically in any publications.

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