概述
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产品名称Anti-IPL-1/STK13/Aurora C抗体[EP1011Y]
参阅全部 IPL-1/STK13/Aurora C 一抗 -
描述兔单克隆抗体[EP1011Y] to IPL-1/STK13/Aurora C
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经测试应用适用于: WBmore details
不适用于: ICC/IF -
种属反应性与反应: Human
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免疫原
A synthetic peptide corresponding to residues near the N-terminus of human Aurora C.
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阳性对照
- HepG2 cell lysate
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常规说明
This product is a recombinant rabbit monoclonal antibody.
Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.
性能
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形式Liquid
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存放说明Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
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存储溶液PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
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纯度Tissue culture supernatant
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克隆单克隆
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克隆编号EP1011Y
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同种型IgG
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研究领域
应用
Our Abpromise guarantee covers the use of ab46783 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
This antibody does not seem to be suitable for ICC/IF (please see abreview).
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
靶标
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功能May play a part in organizing microtubules in relation to the function of the centrosome/spindle pole during mitosis. May also contribute to the regulation of chromosome segregation and cytokinesis.
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组织特异性Isoform 1 and isoform 2 are expressed in testis. Elevated expression levels were seen only in a subset of cancer cells such as HepG2, HuH7 and HeLa cells. Expression is maximum at M phase.
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疾病相关Defects in AURKC are the cause of male infertility with large-headed multiflagellar polyploid spermatozoa (MIMPS) [MIM:243060]; also known as infertility associated with multi-tailed spermatozoa and excessive DNA.
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序列相似性Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
Contains 1 protein kinase domain. -
细胞定位Chromosome. Cytoplasm > cytoskeleton > spindle. Distributes in the condensed chromosomes during prophase to metaphase. After entering anaphase, there is a dissociation from separated chromosomes and a redistribution to midzone microtubules, and finally remaines in the midbody during cytokinesis.
- Information by UniProt
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数据库链接
- Entrez Gene: 6795 Human
- Omim: 603495 Human
- SwissProt: Q9UQB9 Human
- Unigene: 98338 Human
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别名
- AURKC antibody
- AIE 2 antibody
- Aie1 antibody
see all
Anti-IPL-1/STK13/Aurora C antibody [EP1011Y] 图像
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![Western blot - IPL-1/STK13/Aurora C antibody [EP1011Y] - Aminoterminal end (ab46783)](http://www.abcam.cn/ps/datasheet/Images/46/ab46783/46783.jpg)
Western blot - IPL-1/STK13/Aurora C antibody [EP1011Y] - Aminoterminal end (ab46783)Anti-IPL-1/STK13/Aurora C antibody [EP1011Y] (ab46783) at 1/1000 dilution + HepG2 lysate at 10 µg
Secondary
goat anti rabbit HRP at 2000
Predicted band size : 36 kDa
Observed band size : 36 kDa
Anti-IPL-1/STK13/Aurora C antibody [EP1011Y] (ab46783)参考文献
ab46783 has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"