概述

  • 产品名称Anti-IP3KC抗体
    参阅全部 IP3KC 一抗
  • 描述
    兔多克隆抗体to IP3KC
  • 特异性ab65025 detects endogenous levels of total IP3KC protein.
  • 经测试应用适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide derived from an internal sequence of human IP3KC.

  • 阳性对照
    • HT29 cell extracts.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
  • 存储溶液Preservative: 0.02% Sodium Azide
    Constituents: 50% Glycerol, PBS (without Mg2+ and Ca2+), 150mM Sodium chloride, pH 7.4
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab65025 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/10000.
WB 1/500 - 1/1000. Detects a band of approximately 90 kDa (predicted molecular weight: 75 kDa).

靶标

  • 功能Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate.
  • 组织特异性Highly expressed in pancreas, skeletal muscle, liver, placenta and weakly in kidney and brain.
  • 疾病相关Defects in ITPKC are a cause of Kawasaki disease (KWD) [MIM:611775]; also known as mucocutaneous lymph node syndrome or infantile polyarteritis. Kawasaki disease is an acute, self-limited vasculitis of infants and children characterized by prolonged fever unresponsive to antibiotics, polymorphous skin rash, erythema of the oral mucosa, lips, and tongue, erythema of the palms and soles, bilateral conjunctival injection, and cervical lymphadenopathy. Coronary artery aneurysms develop in 15 to 25% of those left untreated, making Kawasaki disease the leading cause of acquired heart disease among children in developed countries.
  • 序列相似性Belongs to the inositol phosphokinase (IPK) family.
  • 细胞定位Nucleus. Cytoplasm. Shuttles actively between nucleus and cytoplasm with both nuclear import and nuclear export activity.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 4 antibody
    • 5-trisphosphate 3-kinase C antibody
    • Inositol 1 antibody
    • inositol 1,4,5 trisphosphate 3 kinase C antibody
    • Inositol trisphosphate 3 kinase C antibody
    • Inositol-trisphosphate 3-kinase C antibody
    • InsP 3 kinase C antibody
    • InsP 3-kinase C antibody
    • IP3 3-kinase C antibody
    • IP3 3KC antibody
    • IP3K C antibody
    • IP3KC antibody
    • IP3KC_HUMAN antibody
    • Itpkc antibody
    see all

Anti-IP3KC antibody 图像

  • All lanes : Anti-IP3KC antibody (ab65025) at 1/500 dilution

    Lane 1 : HT29 cell extract
    Lane 2 : HT29 cell extract with immunising peptide


    Predicted band size : 75 kDa
    Observed band size : 90 kDa (why is the actual band size different from the predicted?)

Anti-IP3KC antibody (ab65025)参考文献

ab65025 has not yet been referenced specifically in any publications.

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