IP3 receptor肽(ab5839)

概述

描述

  • 性质Synthetic

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技术指标

Our Abpromise guarantee covers the use of ab5839 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking

  • 纯度> 95 % SDS-PAGE.

  • 形式Liquid
  • 补充说明


    This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and ITP Receptor Type I, catalog ab5804. Using a solution with equal weights per unit volume of peptide and corresponding antibody will yield a solution with a large molar excess of peptide that is able to competitively bind the antibody.

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名
    • 4
    • 5-trisphosphate receptor
    • 5-trisphosphate receptor type 1
    • DKFZp313E1334
    • DKFZp313N1434
    • Inositol 1
    • inositol 1 4 5 triphosphate receptor type 1
    • Inositol 1 4 5 trisphosphate Receptor Type 1
    • InsP3R1
    • IP3
    • IP3 receptor
    • IP3 receptor isoform 1
    • IP3R
    • IP3R 1
    • IP3R1
    • ITPR 1
    • Itpr1
    • ITPR1_HUMAN
    • SCA15
    • SCA16
    • SCA29
    • Type 1 inositol 1
    • Type 1 inositol 1 4 5 trisphosphate receptor
    • Type 1 InsP3 receptor
    see all
  • 功能Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate.
  • 组织特异性Widely expressed.
  • 疾病相关Defects in ITPR1 are the cause of spinocerebellar ataxia type 15 (SCA15) (SCA15) [MIM:606658]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA15 is an autosomal dominant cerebellar ataxia (ADCA). It is very slow progressing form with a wide range of onset, ranging from childhood to adult. Most patients remain ambulatory.
  • 序列相似性Belongs to the InsP3 receptor family.
    Contains 5 MIR domains.
  • 结构域The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.
  • 翻译后修饰Phosphorylated by cAMP kinase. Phosphorylation prevents the ligand-induced opening of the calcium channels.
    Phosphorylated on tyrosine residues.
  • 细胞定位Endoplasmic reticulum membrane.
  • Information by UniProt

IP3 receptor peptide (ab5839)参考文献

ab5839 has not yet been referenced specifically in any publications.

Product Wall

I would recommend to follow the protocol we have on our website. The use of 2 times the concentration of peptide (compared to the antibody concentration) represents a large and sufficient excess to block the antibody. I hope this is helpful. Do not hes...

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Thank you for confirming these details and for your cooperation. As agreed, I have issued a free of charge replacement with the order number ******. To check the status of the order please contact our Customer Service team and reference this number...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"