概述

描述

  • 性质
    Synthetic

相关产品

技术指标

Our Abpromise guarantee covers the use of ab107795 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 纯度
    70 - 90% by HPLC.

  • 补充说明

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

常规信息

  • 别名
    • 4
    • 5-trisphosphate receptor
    • 5-trisphosphate receptor type 1
    • DKFZp313E1334
    • DKFZp313N1434
    • Inositol 1
    • inositol 1 4 5 triphosphate receptor type 1
    • Inositol 1 4 5 trisphosphate Receptor Type 1
    • InsP3R1
    • IP3
    • IP3 receptor
    • IP3 receptor isoform 1
    • IP3R
    • IP3R 1
    • IP3R1
    • ITPR 1
    • Itpr1
    • ITPR1_HUMAN
    • SCA15
    • SCA16
    • SCA29
    • Type 1 inositol 1
    • Type 1 inositol 1 4 5 trisphosphate receptor
    • Type 1 InsP3 receptor
    see all
  • 功能
    Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate.
  • 组织特异性
    Widely expressed.
  • 疾病相关
    Defects in ITPR1 are the cause of spinocerebellar ataxia type 15 (SCA15) (SCA15) [MIM:606658]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA15 is an autosomal dominant cerebellar ataxia (ADCA). It is very slow progressing form with a wide range of onset, ranging from childhood to adult. Most patients remain ambulatory.
  • 序列相似性
    Belongs to the InsP3 receptor family.
    Contains 5 MIR domains.
  • 结构域
    The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.
  • 翻译后修饰
    Phosphorylated by cAMP kinase. Phosphorylation prevents the ligand-induced opening of the calcium channels.
    Phosphorylated on tyrosine residues.
  • 细胞定位
    Endoplasmic reticulum membrane.
  • Information by UniProt

文献

ab107795 has not yet been referenced specifically in any publications.

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