Anti-IP3 receptor抗体(ab97823)

概述

  • 产品名称Anti-IP3 receptor抗体
    参阅全部 IP3 receptor 一抗
  • 描述
    兔多克隆抗体to IP3 receptor
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Synthetic peptide conjugated to KLH derived from within residues 2700 to the C-terminus of Human ITPR1.

  • 阳性对照
    • This antibody gave a positive signal in HeLa and PC3 Whole Cell Lysates. A band of the expected size was also detected in MALME 3M and Raji Whole Cell Lysates (data not shown). In our hands, the signal was relatively weak in these lysates.

性能

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应用

Our Abpromise guarantee covers the use of ab97823 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Detects a band of approximately 314 kDa (predicted molecular weight: 314 kDa).

靶标

  • 功能Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate.
  • 组织特异性Widely expressed.
  • 疾病相关Defects in ITPR1 are the cause of spinocerebellar ataxia type 15 (SCA15) (SCA15) [MIM:606658]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA15 is an autosomal dominant cerebellar ataxia (ADCA). It is very slow progressing form with a wide range of onset, ranging from childhood to adult. Most patients remain ambulatory.
  • 序列相似性Belongs to the InsP3 receptor family.
    Contains 5 MIR domains.
  • 结构域The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.
  • 翻译后修饰Phosphorylated by cAMP kinase. Phosphorylation prevents the ligand-induced opening of the calcium channels.
    Phosphorylated on tyrosine residues.
  • 细胞定位Endoplasmic reticulum membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 4 antibody
    • 5-trisphosphate receptor antibody
    • 5-trisphosphate receptor type 1 antibody
    • DKFZp313E1334 antibody
    • DKFZp313N1434 antibody
    • inositol 1 4 5 triphosphate receptor type 1 antibody
    • Inositol 1 4 5 trisphosphate Receptor Type 1 antibody
    • Inositol 1 antibody
    • InsP3R1 antibody
    • IP3 antibody
    • IP3 receptor antibody
    • IP3 receptor isoform 1 antibody
    • IP3R 1 antibody
    • IP3R antibody
    • IP3R1 antibody
    • ITPR 1 antibody
    • Itpr1 antibody
    • ITPR1_HUMAN antibody
    • SCA15 antibody
    • SCA16 antibody
    • SCA29 antibody
    • Type 1 inositol 1 4 5 trisphosphate receptor antibody
    • Type 1 inositol 1 antibody
    • Type 1 InsP3 receptor antibody
    see all

Anti-IP3 receptor antibody 图像

  • All lanes : Anti-IP3 receptor antibody (ab97823) at 1 µg/ml

    Lane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate
    Lane 2 : PC3 (Human prostate carcinoma cell line) Whole Cell Lysate Whole Cell Lysate

    Lysates/proteins at 10 µg per lane.

    Secondary
    Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilution
    Developed using the ECL technique

    Performed under reducing conditions.

    Predicted band size : 314 kDa
    Observed band size : 314 kDa
    Additional bands at : 44 kDa. We are unsure as to the identity of these extra bands.

    Exposure time : 12 minutes

Anti-IP3 receptor antibody (ab97823)参考文献

ab97823 has not yet been referenced specifically in any publications.

Product Wall

Thank you very much for your inquiry and your interest in our antibodies. Indeed, we do not have ITPR1 antibodies tested against bovine in our catalogue currently. We are however able to provide you with a testing offer, please see below. ...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"