Anti-Ionotropic Glutamate receptor 4抗体[EPR2511(2)] (ab119995)

概述

• 产品名称
  Anti-Ionotropic Glutamate receptor 4抗体[EPR2511(2)]
  参阅全部 Ionotropic Glutamate receptor 4 一抗
• 描述
  兔单克隆抗体[EPR2511(2)] to Ionotropic Glutamate receptor 4
• 经测试应用
  适用于: WBmore details
  不适用于: Flow Cyt,ICC,IHC-P or IP
• 种属反应性
  与反应: Mouse, Rat, Human
  
• 免疫原

  Synthetic peptide, corresponding to residues in the extracellular domain of Human Ionotropic Glutamate receptor 4.

• 阳性对照
  • Rat Brain, Mouse Brain and Human Brain lysates
• 常规说明

  This product is a recombinant rabbit monoclonal antibody.

  Produced using Abcam’s RabMAb^® technology. RabMAb^® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

性能

• 形式
  Liquid
• 存放说明
  Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
• 存储溶液
  PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
• 纯度
  Tissue culture supernatant
• 克隆
  单克隆
• 克隆编号
  EPR2511(2)
• 同种型
  IgG
• 研究领域
  • Neuroscience
  • Neurotransmission
  • Receptors / Channels
  • GPCR
  • Glutamate Receptors

  • Signal Transduction
  • Signaling Pathway
  • G Protein Signaling
  • GPCR

相关产品

• Positive Controls
  • Rat brain normal tissue lysate - membrane extract (ab29473)

应用

靶标

• 功能
  Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.
• 序列相似性
  Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA4 subfamily.
• 翻译后修饰
  Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-611 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-837 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis.
• 细胞定位
  Cell membrane. Cell junction > synapse > postsynaptic cell membrane.

• Target information above from: UniProt accession P48058 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 数据库链接
  • Entrez Gene: 2893 Human
  • Entrez Gene: 14802 Mouse
  • Entrez Gene: 29629 Rat
  • Omim: 138246 Human
  • SwissProt: P48058 Human
  • SwissProt: Q9Z2W8 Mouse
  • SwissProt: P19493 Rat
  • Unigene: 503743 Human

  • Unigene: 209263 Mouse
  • Unigene: 10938 Rat

  see all
• 别名
  • AMPA 4 antibody
  • AMPA selective glutamate receptor 4 antibody
  • AMPA-selective glutamate receptor 4 antibody

  • AMPA4 antibody
  • GluA 4 antibody
  • GluA4 antibody
  • GluR 4 antibody
  • GluR D antibody
  • GluR-4 antibody
  • GluR-D antibody
  • GluR4 antibody
  • GLUR4C antibody
  • GLURD antibody
  • Glutamate receptor 4 antibody
  • Glutamate receptor ionotrophic AMPA 4 antibody
  • Glutamate receptor ionotropic antibody
  • GRIA 4 antibody
  • Gria4 antibody
  • GRIA4_HUMAN antibody

  see all

实验方案

• Western blot protocols