Anti-Ionotropic Glutamate receptor 4抗体[EPR2511(2)] (ab119995)
概述
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产品名称Anti-Ionotropic Glutamate receptor 4抗体[EPR2511(2)]
参阅全部 Ionotropic Glutamate receptor 4 一抗 -
描述兔单克隆抗体[EPR2511(2)] to Ionotropic Glutamate receptor 4
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宿主Rabbit
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经测试应用适用于: WBmore details
不适用于: Flow Cyt,ICC,IHC-P or IP -
种属反应性与反应: Mouse, Rat, Human
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免疫原
Synthetic peptide, corresponding to residues in the extracellular domain of Human Ionotropic Glutamate receptor 4.
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阳性对照
- Rat Brain, Mouse Brain and Human Brain lysates
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常规说明
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents
This product is a recombinant rabbit monoclonal antibody.
性能
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形式Liquid
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存放说明Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
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存储溶液PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
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纯度Tissue culture supernatant
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克隆单克隆
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克隆编号EPR2511(2)
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同种型IgG
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研究领域
相关产品
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Positive Controls
应用
Our Abpromise guarantee covers the use of ab119995 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB | 1/1000 - 1/10000. Detects a band of approximately 100 kDa (predicted molecular weight: 101 kDa). |
靶标
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功能Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.
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序列相似性Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA4 subfamily.
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翻译后修饰Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-611 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-837 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis.
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细胞定位Cell membrane. Cell junction > synapse > postsynaptic cell membrane.
- Information by UniProt
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数据库链接
- Entrez Gene: 2893 Human
- Entrez Gene: 14802 Mouse
- Entrez Gene: 29629 Rat
- Omim: 138246 Human
- SwissProt: P48058 Human
- SwissProt: Q9Z2W8 Mouse
- SwissProt: P19493 Rat
- Unigene: 503743 Human
see all -
别名
- AMPA 4 antibody
- AMPA selective glutamate receptor 4 antibody
- AMPA-selective glutamate receptor 4 antibody
see all
图片
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![Western blot - Anti-Ionotropic Glutamate receptor 4 antibody [EPR2511(2)] (ab119995)](http://www.abcam.cn/ps/datasheet/images/119/ab119995/Ionotropic-Glutamate-receptor-4-Primary-antibodies-ab119995-2.jpg)
Western blot - Anti-Ionotropic Glutamate receptor 4 antibody [EPR2511(2)] (ab119995)All lanes : Anti-Ionotropic Glutamate receptor 4 antibody [EPR2511(2)] (ab119995) at 1/1000 dilution
Lane 1 : Rat Brain lysate
Lane 2 : Mouse Brain lysate
Lane 3 : Human Brain lysate
Lysates/proteins at 10 µg per lane.
Secondary
All lanes : HRP labelled goat anti-rabbit at 1/2000 dilution
Predicted band size: 101 kDa
文献
ab119995 has not yet been referenced specifically in any publications.
客户评价及客户问答
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"