Anti-Ionotropic Glutamate receptor 4抗体(ab61171)

概述

  • 产品名称Anti-Ionotropic Glutamate receptor 4抗体
    参阅全部 Ionotropic Glutamate receptor 4 一抗
  • 描述
    兔多克隆抗体to Ionotropic Glutamate receptor 4
  • 特异性Detects total ionotropic Glutamate Receptor 4 levels.
  • 经测试应用适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Synthetic non-phosphopeptide derived from human ionotropic Glutamate Receptor 4 around the phosphorylation site of serine 862 (R-L-SP-I-T).

性能

应用

Our Abpromise guarantee covers the use of ab61171 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/20000.
WB 1/500 - 1/1000. Detects a band of approximately 102 kDa (predicted molecular weight: 102 kDa).

靶标

  • 功能Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.
  • 序列相似性Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA4 subfamily.
  • 翻译后修饰Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-611 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-837 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis.
  • 细胞定位Cell membrane. Cell junction > synapse > postsynaptic cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • AMPA 4 antibody
    • AMPA selective glutamate receptor 4 antibody
    • AMPA-selective glutamate receptor 4 antibody
    • AMPA4 antibody
    • GluA 4 antibody
    • GluA4 antibody
    • GluR 4 antibody
    • GluR D antibody
    • GluR-4 antibody
    • GluR-D antibody
    • GluR4 antibody
    • GLUR4C antibody
    • GLURD antibody
    • Glutamate receptor 4 antibody
    • Glutamate receptor ionotrophic AMPA 4 antibody
    • Glutamate receptor ionotropic antibody
    • GRIA 4 antibody
    • Gria4 antibody
    • GRIA4_HUMAN antibody
    see all

Anti-Ionotropic Glutamate receptor 4 antibody 图像

  • All lanes : Anti-Ionotropic Glutamate receptor 4 antibody (ab61171) at 1/500 dilution

    Lane 1 : NIH 3T3 cell extracts treated with Forskolin (40nM, 30mins)
    Lane 2 : NIH 3T3 cell extracts treated with Forskolin (40nM, 30mins) with immunising peptide


    Predicted band size : 102 kDa
    Observed band size : 102 kDa

Anti-Ionotropic Glutamate receptor 4 antibody (ab61171)参考文献

ab61171 has not yet been referenced specifically in any publications.

Product Wall

Abcam guarantees this product to work in the species/application used in this Abreview.
Application ELISA
Sample Human Recombinant protein (RLSIT motive peptide)
Specification RLSIT motive peptide
Type Direct
Username

Abcam user community

Verified customer

提交于 Mar 14 2013

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"