Anti-Ionotropic Glutamate receptor 2 (phospho S880)抗体(ab52180)

概述

  • 产品名称Anti-Ionotropic Glutamate receptor 2 (phospho S880)抗体
    参阅全部 Ionotropic Glutamate receptor 2 一抗
  • 描述
    兔多克隆抗体to Ionotropic Glutamate receptor 2 (phospho S880)
  • 特异性Detects endogenous levels of Glutamate receptor 2 only when phosphorylated at serine 880.
  • 经测试应用适用于: ELISA, IHC-P, WBmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Synthetic phosphopeptide derived from human Glutamate receptor 2 around the phosphorylation site of serine 880 (I-E-SP-V-K).

  • 阳性对照
    • Extracts from mouse brain, human brain tissue.

性能

应用

Our Abpromise guarantee covers the use of ab52180 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/20000.
IHC-P Use at an assay dependent concentration.
WB 1/500 - 1/1000. Detects a band of approximately 99 kDa (predicted molecular weight: 99 kDa).

靶标

  • 功能Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
  • 序列相似性Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA2 subfamily.
  • 翻译后修饰Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-610 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-836 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis.
  • 细胞定位Cell membrane. Endoplasmic reticulum membrane. Cell junction > synapse > postsynaptic cell membrane. Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression.
  • Information by UniProt
  • 数据库链接
  • 别名
    • AMPA 2 antibody
    • AMPA selective glutamate receptor 2 antibody
    • AMPA-selective glutamate receptor 2 antibody
    • AMPA2 antibody
    • GluA2 antibody
    • GLUR 2 antibody
    • GLUR B antibody
    • GluR K2 antibody
    • GluR-2 antibody
    • GluR-B antibody
    • GluR-K2 antibody
    • GLUR2 antibody
    • GLURB antibody
    • Glutamate receptor 2 antibody
    • Glutamate receptor ionotropic AMPA 2 antibody
    • Glutamate receptor ionotropic antibody
    • Gria2 antibody
    • GRIA2_HUMAN antibody
    • HBGR2 antibody
    see all

Anti-Ionotropic Glutamate receptor 2 (phospho S880) antibody 图像

  • All lanes : Anti-Ionotropic Glutamate receptor 2 (phospho S880) antibody (ab52180) at 1/500 dilution

    Lane 1 : extracts from mouse brain
    Lane 2 : extracts from mouse brain with blocking phosphopeptide


    Predicted band size : 99 kDa
  • Ab52180 at 1/50 dilution staining Human brain tissue, with and without blocking peptide; paraffin embedded.

Anti-Ionotropic Glutamate receptor 2 (phospho S880) antibody (ab52180)参考文献

This product has been referenced in:
  • Castilho AF  et al. Diabetes causes transient changes in the composition and phosphorylation of a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors and interaction with auxiliary proteins in the rat retina. Mol Vis 20:894-907 (2014). WB ; Rat . Read more (PubMed: 24966661) »
  • Miñano-Molina AJ  et al. Soluble Oligomers of Amyloid-{beta} Peptide Disrupt Membrane Trafficking of {alpha}-Amino-3-hydroxy-5-methylisoxazole-4-propionic Acid Receptor Contributing to Early Synapse Dysfunction. J Biol Chem 286:27311-21 (2011). WB ; Mouse . Read more (PubMed: 21665950) »

See all 3 Publications for this product

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