Anti-Ionotropic Glutamate receptor 2 (phospho S880)抗体(ab52180)

概述

  • 产品名称
    Anti-Ionotropic Glutamate receptor 2 (phospho S880)抗体
    参阅全部 Ionotropic Glutamate receptor 2 一抗
  • 描述
    兔多克隆抗体to Ionotropic Glutamate receptor 2 (phospho S880)
  • 特异性
    Detects endogenous levels of Glutamate receptor 2 only when phosphorylated at serine 880.
  • 经测试应用
    适用于: ELISA, IHC-P, WBmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Synthetic phosphopeptide derived from human Glutamate receptor 2 around the phosphorylation site of serine 880 (I-E-SP-V-K).

  • 阳性对照
    • Extracts from mouse brain, human brain tissue.

性能

应用

Our Abpromise guarantee covers the use of ab52180 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/20000.
IHC-P Use at an assay dependent concentration.
WB 1/500 - 1/1000. Detects a band of approximately 99 kDa (predicted molecular weight: 99 kDa).

靶标

  • 功能
    Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
  • 序列相似性
    Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA2 subfamily.
  • 翻译后修饰
    Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-610 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-836 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis.
  • 细胞定位
    Cell membrane. Endoplasmic reticulum membrane. Cell junction > synapse > postsynaptic cell membrane. Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression.
  • Information by UniProt
  • 数据库链接
  • 别名
    • AMPA 2 antibody
    • AMPA selective glutamate receptor 2 antibody
    • AMPA-selective glutamate receptor 2 antibody
    • AMPA2 antibody
    • GluA2 antibody
    • GLUR 2 antibody
    • GLUR B antibody
    • GluR K2 antibody
    • GluR-2 antibody
    • GluR-B antibody
    • GluR-K2 antibody
    • GLUR2 antibody
    • GLURB antibody
    • Glutamate receptor 2 antibody
    • Glutamate receptor ionotropic AMPA 2 antibody
    • Glutamate receptor ionotropic antibody
    • Gria2 antibody
    • GRIA2_HUMAN antibody
    • HBGR2 antibody
    see all

Anti-Ionotropic Glutamate receptor 2 (phospho S880) antibody 图像

  • All lanes : Anti-Ionotropic Glutamate receptor 2 (phospho S880) antibody (ab52180) at 1/500 dilution

    Lane 1 : extracts from mouse brain
    Lane 2 : extracts from mouse brain with blocking phosphopeptide


    Predicted band size : 99 kDa
  • Ab52180 at 1/50 dilution staining Human brain tissue, with and without blocking peptide; paraffin embedded.

Anti-Ionotropic Glutamate receptor 2 (phospho S880) antibody (ab52180)参考文献

This product has been referenced in:
  • Bonini D  et al. Acute Footshock Stress Induces Time-Dependent Modifications of AMPA/NMDA Protein Expression and AMPA Phosphorylation. Neural Plast 2016:7267865 (2016). WB . Read more (PubMed: 26966584) »
  • Hao JR  et al. L-Stepholidine rescues memory deficit and synaptic plasticity in models of Alzheimer's disease via activating dopamine D1 receptor/PKA signaling pathway. Cell Death Dis 6:e1965 (2015). WB . Read more (PubMed: 26539912) »

See all 6 Publications for this product

Product Wall

There are currently no Abreviews or Questions for ab52180.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

注册