概述

  • 产品名称
    Anti-Involucrin抗体
    参阅全部 Involucrin 一抗
  • 描述
    兔多克隆抗体to Involucrin
  • 特异性
    ab27495 recognises Involucrin.
  • 经测试应用
    适用于: IHC-P, WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment, corresponding to amino acids 420/578 of Human Involucrin

  • 阳性对照
    • Human skin

性能

应用

Our Abpromise guarantee covers the use of ab27495 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/100. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 68 kDa.

靶标

  • 功能
    Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.
  • 组织特异性
    Keratinocytes of epidermis and other stratified squamous epithelia.
  • 序列相似性
    Belongs to the involucrin family.
  • 翻译后修饰
    Substrate of transglutaminase. Some glutamines and lysines are cross-linked to other involucrin molecules, to other proteins such as keratin, desmoplakin, periplakin and envoplakin, and to lipids like omega-hydroxyceramide.
  • 细胞定位
    Cytoplasm. Constituent of the scaffolding of the cornified envelope.
  • Information by UniProt
  • 数据库链接
  • 别名
    • INVO_HUMAN antibody
    • Involucrin antibody
    • IVL antibody

图片

  • Paraffin embedded formalin fixed human skin tissue section stained with anti Involucrin (ab27495).

文献

This product has been referenced in:
  • Melo SP  et al. Somatic correction of junctional epidermolysis bullosa by a highly recombinogenic AAV variant. Mol Ther 22:725-33 (2014). ICC/IF ; Human . Read more (PubMed: 24390279) »
  • Lamb R & Ambler CA Keratinocytes propagated in serum-free, feeder-free culture conditions fail to form stratified epidermis in a reconstituted skin model. PLoS One 8:e52494 (2013). ICC/IF ; Human . Read more (PubMed: 23326335) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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