Anti-Interferon Receptor alpha抗体[MM0336-8H46] (ab90498)

概述

  • 产品名称Anti-Interferon Receptor alpha抗体[MM0336-8H46]
    参阅全部 Interferon Receptor alpha 一抗
  • 描述
    小鼠单克隆抗体[MM0336-8H46] to Interferon Receptor alpha
  • 经测试应用适用于: WB, Flow Cytmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment, corresponding to the extracellular domain of Human Interferon Receptor alpha.

  • 阳性对照
    • U937 human lymphoma cell line.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: None
    Constituents: PBS
  • Concentration information loading...
  • 纯度Protein G purified
  • 纯化说明The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and 0.2 µm filtered.
  • 克隆单克隆
  • 克隆编号MM0336-8H46
  • 同种型IgG1
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab90498 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/2000. Predicted molecular weight: 64 kDa.
Flow Cyt 1/50 - 1/200. ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

靶标

  • 相关性Interferon Receptor alpha (IFN-a R1) is a class II cytokine receptor which belongs to type I human interferons (IFNs) family. IFNs plays a role in antiviral, antiproliferative, immunomodulatory, antitumor, and antiparasitic activities by inducing transcription of IFN-stimuated genes (ISGs) through activation of the Jak-STAT pathway. Specifically, Interferon Receptor alpha is a 135-kda signal transducing subunit of the IFN alpha/beta receptor complex (IFN-a R). Interferon Receptor alpha is phospholyated through PTK- and PKC-mediated phosphorylation, which initiates docking of STAT proteins to IFNs. This leads to activation of STAT proteins by PTK-mediated phosphorylation. The mechanism behind the amplification of Interferon Receptor alpha complex mediated transmembrane signaling has been linked to tyrosine phosphorylation on Interferon Receptor alpha. IFNAR1 possesses a large N-glycosylated ectodomain.
  • 细胞定位Membrane; single-pass type I membrane protein.
  • 数据库链接
  • 别名
    • AVP antibody
    • IFN alpha R1 antibody
    • IFN alpha REC antibody
    • IFNAR antibody
    • IFNAR1 antibody
    • IFNBR antibody
    • IFRC antibody
    • interferon (alpha beta and omega) receptor 1 antibody
    • Interferon alpha receptor 1 antibody
    • Interferon alpha/beta receptor alpha chain antibody
    see all

Anti-Interferon Receptor alpha antibody [MM0336-8H46] (ab90498)参考文献

ab90498 has not yet been referenced specifically in any publications.

Product Wall

Thank you for contacting us. The lab tested this antibody in Flow Cytometry on the U937 human lymphoma cell line. I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"